: Fc gamma receptor IIB is an important regulator of immuno-reactivity. Genetic disruption of the Fc gamma receptor results in a fulminate, lupus-like disease in the C57BL/6 murine background. The goal of this project is to more closely examine the lupus which arises in these animals to determine the effect that Fc gamma receptor IIB disruption has on the B cell repertoire and on silencing of auto-reactive B cells in the periphery. In addition, these studies investigate the nature of chromatin tolerance in these animals (i.e. is the loss of tolerance reversible or is it a permanent physiological change) by reestablishment of the Fc gamma receptor IIB regulatory pathway in animals with established autoimmunity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AI055181-02
Application #
6758677
Study Section
Special Emphasis Panel (ZRG1-F07 (20))
Program Officer
Prograis, Lawrence J
Project Start
2003-06-01
Project End
2006-05-31
Budget Start
2004-06-01
Budget End
2005-05-31
Support Year
2
Fiscal Year
2004
Total Cost
$47,296
Indirect Cost
Name
Rockefeller University
Department
Genetics
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065