The risk of cardiovascular disease (CVD) and fractures due to osteoporosis (OP) is increased in systemic lupus erythematosus (SLE) patients. Autoimmune-mediated mechanisms that underlie pathogenesis in SLE have also been implicated in CVD and OP. The role of autoimmune markers (defined by anti-phospholipid, anti-oxLDL and anti-MDA-LDL antibodies) in subclinical CVD and OP (measured by vascular calcification, carotid plaque, intima-media thickness, and bone mineral density) will be examined in 200 SLE women. A pilot project will be conducted to evaluate the correlation between flow-mediated brachial reactivity and more established surrogate measures of CVD, as well as autoimmune markers. This work presents the unique opportunity to examine autoimmune markers as potential biologic links underlying the pathogenesis of OP and CVD in SLE patients. The research goals of this award are to: 1) pursue formal course work culminating in a MS degree in Clinical Investigation, 2) submit manuscripts related to the specific aims delineated in this proposal, and 3) develop and execute a pilot study. The project outlined in this proposal will provide a strong foundation for achieving my ultimate goal of becoming an independent clinical investigator. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32AR051681-02
Application #
6960022
Study Section
Special Emphasis Panel (ZRG1-F07 (20))
Program Officer
Serrate-Sztein, Susana
Project Start
2005-01-01
Project End
2006-12-31
Budget Start
2006-01-01
Budget End
2006-12-31
Support Year
2
Fiscal Year
2006
Total Cost
$55,852
Indirect Cost
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Lin, Pin; Rhew, Elisa; Ness, Roberta B et al. (2014) Adverse pregnancy outcomes and subsequent risk of cardiovascular disease in women with systemic lupus erythematosus. Lupus Sci Med 1:e000024
Wu, Peggy W; Rhew, Elisa Y; Dyer, Alan R et al. (2009) 25-hydroxyvitamin D and cardiovascular risk factors in women with systemic lupus erythematosus. Arthritis Rheum 61:1387-95
Rhew, Elisa Y; Manzi, Susan M; Dyer, Alan R et al. (2009) Differences in subclinical cardiovascular disease between African American and Caucasian women with systemic lupus erythematosus. Transl Res 153:51-9
Suresh, Sangita; Demirci, F Yesim K; Jacobs, Erin et al. (2009) Apolipoprotein H promoter polymorphisms in relation to lupus and lupus-related phenotypes. J Rheumatol 36:315-22
Rhew, Elisa Y; Lee, Chin; Eksarko, Polikseni et al. (2008) Homocysteine, bone mineral density, and fracture risk over 2 years of followup in women with and without systemic lupus erythematosus. J Rheumatol 35:230-6
Demirci, F Yesim K; Manzi, Susan; Ramsey-Goldman, Rosalind et al. (2007) Association study of Toll-like receptor 5 (TLR5) and Toll-like receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus. J Rheumatol 34:1708-11
Demirci, F Y K; Manzi, S; Ramsey-Goldman, R et al. (2007) Association of a common interferon regulatory factor 5 (IRF5) variant with increased risk of systemic lupus erythematosus (SLE). Ann Hum Genet 71:308-11
Rhew, Elisa Y; Ramsey-Goldman, Rosalind (2006) Premature atherosclerotic disease in systemic lupus erythematosus--role of inflammatory mechanisms. Autoimmun Rev 5:101-5