Understanding how tumor suppressor gene works will solve how the cell controls its growth and differentiation, how a multi-cellular organism develops from a single cell and how fundamental processes such as transcription is regulated. Subtractive hybridization method will be used to identify physiologic target genes of a tumor suppressor WT1. Identifying genuine targets of WT1 will further our understanding of the mechanism of tumor suppressor genes and provide a foundation for clinical manipulations of this important disease.
| Lee, S B; Huang, K; Palmer, R et al. (1999) The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin. Cell 98:663-73 |
| Lee, S B; Kolquist, K A; Nichols, K et al. (1997) The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour. Nat Genet 17:309-13 |
