The molecular mechanism by which Wnt signaling pathways regulate the growth of prostate cells has not been elucidated. Particularly, the identities of the receptors (Frizzled) that selectively express in prostate cancer cells are not known. Furthermore, the biological role Frizzleds play in mediating these signaling pathways during prostate cancer development and progression are not understood. Therefore, identification and characterization of the Frizzled proteins that selectively express in prostate cells and regulate the cell growth of prostate cancer will be very important for understanding the pathogenesis and progression of prostate cancer. The major of objective of this proposal is to investigate the expression and function of Frizzled proteins that are selectively expressed in prostate cancer cells in order to fully understand the biological role of the Wnt signaling pathway in the tumorigenesis of prostate cancer.
Three specific aims are proposed in this fellowship, which include (1) Identification of the Frizzled proteins that selectively express in prostate cancer cell lines and prostate cancer tissues; (2) Investigate the biological role of Frizzled proteins in prostate cancer cells; (3) Study the biological role of Frizzleds in the pathogenesis of prostate cancer. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32CA119636-04
Application #
7406000
Study Section
Special Emphasis Panel (ZRG1-F09 (20))
Program Officer
Jakowlew, Sonia B
Project Start
2006-05-05
Project End
2009-05-04
Budget Start
2008-05-05
Budget End
2009-05-04
Support Year
4
Fiscal Year
2008
Total Cost
$50,428
Indirect Cost
Name
University of California San Francisco
Department
Surgery
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Bravo, Dawn T; Yang, Yi-Lin; Kuchenbecker, Kristopher et al. (2013) Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer. BMC Cancer 13:316