The population of elderly in the United States will be more than doubled, numbering to 72.1 million, from 2000 to 2030. The roughness of voice and decline of voice quality are ubiquitous signs of aging. The vibratory characteristics of the vocal folds are largely governed by the stiffness conditions in the vocal folds lamina propria (LP). The stiffness is determined by the nonlinearity and anisotropy of vocal fold LP mechanical properties resulting from the structural properties of the extracellular matrix. Therefore, knowledge of alterations in the LP mechanical and microstructural properties with age can elucidate the primary causes affecting mucosal wave, vocal fold vibration and voice quality in elderly. The goal of this research proposal is three-fold: First, to determine the inherent nonlinearity and anisotropy of the LP mechanical properties and their influence on the pitch range and closure pattern, based on in vitro phonation measurements, as a function of age;secondly, to determine the underlying contribution of elastin and collagen material properties to the mechanical behavior, and delineate the alterations in these properties with age.

Public Health Relevance

In Western societies, the increasing life expectancy and declining birth rates have resulted in an ever-rising number of people older than 65 years. The universal signs of aging are roughness of voice and decline of voice quality. This premise of this proposal is that in order to devise the effective therapies, and hopefully the successful preventive measures, for the aging voice, the effects of the natural aging process need to be fully comprehended.

National Institute of Health (NIH)
Postdoctoral Individual National Research Service Award (F32)
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Special Emphasis Panel (ZDC1)
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Sklare, Dan
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University of California Los Angeles
Schools of Medicine
Los Angeles
United States
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Gordon, Katherine R; McGregor, Karla K; Waldier, Brigitte et al. (2016) Preschool Children's Memory for Word Forms Remains Stable Over Several Days, but Gradually Decreases after 6 Months. Front Psychol 7:1439