The reciprocal relationship between the gut microbiota and its human host is extremely complex. The dynamic changes that occur in gut microbiota in response to its host physiological state and the influence it has on human physiology are poorly understood. Evidence has suggested that the gut microbiota can influence glucose metabolism. Despite these findings, the role of the microbiota in the onset and development of type 2 diabetes mellitus (T2D) has yet to be fully understood. We propose to apply an omics-centric approach in which many genes, proteins, metabolites and cytokines comprising functional pathways in both the host and the microbiome are interrogated for quantitative changes associated with the onset and development of T2D. Through longitudinal in-depth profiling of the host and the microbiota, we will identify molecular and biochemical signatures for the host and the microbiota associated with the development of T2D. The integration and temporal profiles of these data will provide an unprecedented view of the global host-microbiota changes that occur during the transition to T2D.

Public Health Relevance

Public Health Relevance Statement: The gut microbiome is thought to have an enormous influence on human health; however, how the composition of the microbiome correlates and contributes to the phenotype of its human host is poorly understood. Performing detailed analysis of the gut microbiome interaction with its human host using high-throughput omics approaches we hope to understand the role of the gut microbiome in the onset of type 2 diabetes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32DK104460-02
Application #
8995119
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Densmore, Christine L
Project Start
2015-01-01
Project End
2017-12-31
Budget Start
2016-01-01
Budget End
2016-12-31
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Stanford University
Department
Genetics
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94304