The long-term objectives of this research proposal are to understand the function of D-serine in the rabbit retina and how it modulates the excitability of ganglion and amacrine cells through its actions as the endogenous coagonist of NMDA receptors. D-serine is synthesized and released by Muller cells and astrocytes and represents a new form of glial-neuronal modulation. Electrophysiological methods will be used to evaluate the direct actions of applied D-serine and reductions of endogenous D-serine will be achieved through biochemical/pharmacological methods. It is essential to understand the importance of Dserine in the retina, because NMDA receptors have been implicated in many functions of nervous tissue, including excitoxicity effects mediated through excessive stimulation by glutamate released from ischemic or diseased tissue. In addition, D-serine is presently given in large quantities for therapeutic purposes to psychiatric patients. Because D-serine can cross the blood brain barrier, it undoubtedly can enter the retina. Thus D-serine represents a potential health risk to the retina and knowledge of its actions and regulation in the retina are essential if D-serine becomes approved therapy for patients.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32EY016307-02
Application #
7007655
Study Section
Special Emphasis Panel (ZRG1-F03B (20))
Program Officer
Hunter, Chyren
Project Start
2004-12-01
Project End
2007-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
2
Fiscal Year
2006
Total Cost
$48,851
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Neurosciences
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455