Binocularvisionisimportantformanyeverydayactivities,anditsdevelopmentreliesonthecouplingof accuratebinoculareyemovementswithstereoscopicfusion.However,thesemechanismsdonotdevelop properlyin2-5%ofthepopulation,whohavechronicimpairmentsintheformofstrabismusandamblyopia. Evaluatingandtreatingstrabismusisparticularlychallengingduetothelimitedavailabilityofautomated assessmentsorrehabilitationproceduresformovingeyesinmultiplepostures.Ascientificunderstandingof thesensoryandoculomotorimpairmentsinstrabismuswillinformclinicalassessmentandlaythefoundation fornewevidence-basedtherapies.Therefore,thegoalsofthisprojectaretotranslatelaboratory-basedeye trackingprocedurestotheclinicwheretheycanautomaticallyquantifythemagnitudeofstrabismusacross differentgazepostures,andthentorelatethesemeasurementstofunctionalimpairmentsinbinocularvision.A thirdgoalistousethesamemethodologicaltechniquestoexaminewhethersensoryandmotordeficitsin strabismuscanbemanipulatedusinganoveloculomotoradaptationprocedure.
Aim1 willdrawonbothwell-establishedclinicalassessmentmethodsandhigh-speedeyetrackingtoquantify themagnitudeandvariabilityofocularmisalignmentacrossdifferentgazeposturesinobserverswithand withoutstrabismus.Inaddition,patients?binocularvisualdeficitswillbemeasuredatthesameposturesto examinetherelationshipbetweenthemagnitudeofmisalignmentandbinocularvisualfunctionforagivengaze direction.Thisvariationisimportanttocapture,asithasbeenshownthatnormally-sightedobserverswithout strabismusexhibitocularmisalignment,andevenstereoblindness,atcertaingazedirections.
Aim2 willdraw onthetechniquesdevelopedinAim1toevaluatetheperceptualandmotoreffectsofdichopticoculomotor adaptation.Previousworkwithnormally-sightedobservershasshownthateyemovementamplitudescanbe adaptivelyrecalibratedinoppositedirectionsinthetwoeyes,buttheshort-termperceptualconsequencesof thisadaptationhavenotbeeninvestigatedineithernormally-sightedsubjectsorpatientswithstrabismus.The resultsofAim2willprovideinsightsintooculomotorplasticityinpatientswithstrabismus,akeystepin developingnon-invasivetherapies.

Public Health Relevance

Strabismusaffects2-5%ofthepopulationandisassociatedwithasyndromeofvisualdeficits,including impairedstereovisionandthesuppressionofvisualinputfromoneeye.Thisprojectwilluseeyetracking methodstomeasureoculomotorandsensorydeficitsinstrabismusatdifferentgazepostures,andtotest whethertheycanbetransientlycorrectedwithafeedback-basedtrainingprocedure.Anunderstandingof theseimpairmentsandhowtheycanbemanipulatedwillguidethedevelopmentofnewassessmentsand treatmentsforstrabismus.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32EY028814-02
Application #
9657546
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Agarwal, Neeraj
Project Start
2018-01-24
Project End
2021-01-23
Budget Start
2019-01-24
Budget End
2020-01-23
Support Year
2
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Northeastern University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
001423631
City
Boston
State
MA
Country
United States
Zip Code
Vera-Diaz, Fuensanta A; Bex, Peter J; Ferreira, Adriana et al. (2018) Binocular temporal visual processing in myopia. J Vis 18:17