The purpose of the proposed research program is to develop a general and efficient route to a structurally complex and biologically important molecule, norzoanthamine. Norzoanthamine hydrochloride suppresses the decrease in bone weight and strength in ovariectomized mice, which could make this compound a good candidate for an osteoporotic drug. Simple norzoanthamine analogues may retain anti-osteoporotic activity and allow easy preparation of potential osteoporotic drugs. Also, analogue preparation may provide valuable information on the biogenesis and mechanism of biological action of these compounds, since studies in these areas remain unexplored. Determining structure-activity relationships is crucial for understanding the mode of actions of norzoanthamine. Since norzoanthamine is isolated from the rare colonial zoanthid of these genus Zoanthus, only small amounts of sample can be obtained this way and it is for this reason that a total synthesis will also be quite beneficial.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32GM019988-02
Application #
6178898
Study Section
Medicinal Chemistry Study Section (MCHA)
Program Officer
Ikeda, Richard A
Project Start
2000-08-02
Project End
Budget Start
2000-08-02
Budget End
2001-08-01
Support Year
2
Fiscal Year
2000
Total Cost
$32,416
Indirect Cost
Name
Harvard University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138