During neural development, cellular differentiation of precursor cells generate a precise pattern within the embryo that is required for proper function. Cells are specified by receiving a series of inductive signals from the environment or within the cell itself, that instructs the cell toward a specific program of differentiation. A model system for studying the molecular events of neural development in the embryonic zebrafish. Due to the ability to perform large scale genetic screens, anamniotic mode of development, [d generation time and optical lucidity offers ideal conditions to study events in early embryogenesis invertebrates. The process of dorsal neural tube and neural crest formation and migration is a ideal system studying Patterning events during neural development. The specific goal of this proposal is to identify characterize genetic mutants that have specific defects in the dorsal neural tube. To this end, a large e genetic screen will be initiated to specifically screen using a battery of molecular probes, for dorsal neural tube mutants. Once these mutants are identified, it is the long term goal of this proposal to initiate cloning strategies and embryological techniques to determine the role of these genetic loci during development.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32HD008209-04
Application #
2888782
Study Section
Biological Sciences 2 (BIOL)
Program Officer
Henken, Deborah B
Project Start
1999-04-01
Project End
Budget Start
1999-04-01
Budget End
2000-05-31
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Harvard University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115