A growing body of literature has documented the frequent occurence of impaired awareness of deficits Following traumatic brain injury (TBI) and its potential implication for rehabilitation. Despite its clinical significance, current understanding of this construct has been limited by factors such as frequent utilization of clinical/convenience samples and lack of clinical comparison groups in the literature. Further, the course of awareness deficits over time is poorly understood due to a lack of longitudinal studies. This study aims to advance our current understanding of awareness by exploring this construct in a non-select group of TBI patients from one month to three to five years post injury. Awareness will be measured in terms of discrepancy between patient's self-report of functioning and the report of their significant other. This study will provide information about the incidence of awareness deficits in TBI over time and clarify the contribution of patient related (e.g., emotional status, neuropsychological impairments, TBI severity) and significant other related variables (e.g., depression of significant other, burden of caring for patient) that predict poor rating concordance. Finally, a general trauma comparison group will be utilized to evaluate the unique contribution of cognitive impairments associated with TBI to awareness. This study will provide significant information about the mechanisms underlying poor rating concordance and awareness, which should have implications for understanding complicated clinical recoveries and targeted rehabilitation interventions. ? ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32HD048030-02
Application #
6937197
Study Section
Behavioral Medicine, Interventions and Outcomes Study Section (BMIO)
Program Officer
Nitkin, Ralph M
Project Start
2004-08-01
Project End
2006-07-31
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
2
Fiscal Year
2005
Total Cost
$42,976
Indirect Cost
Name
University of Washington
Department
Physical Medicine & Rehab
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Pagulayan, Kathleen Farrell; Hoffman, Jeanne M; Temkin, Nancy R et al. (2008) Functional limitations and depression after traumatic brain injury: examination of the temporal relationship. Arch Phys Med Rehabil 89:1887-92
Pagulayan, Kathleen Farrell; Temkin, Nancy R; Machamer, Joan E et al. (2007) The measurement and magnitude of awareness difficulties after traumatic brain injury: a longitudinal study. J Int Neuropsychol Soc 13:561-70
Pagulayan, Kathleen F; Temkin, Nancy R; Machamer, Joan et al. (2006) A longitudinal study of health-related quality of life after traumatic brain injury. Arch Phys Med Rehabil 87:611-8