Abstract

The proposal is for a method for base calling to detect polymorphism rates in pools of DNA samples. The idea is to adapt the computer program PolyPhred that can score heterozygosity in diploid samples, to be able to score allele frequencies in pooled DNA samples. Application of the new program, PolyPop, to TCR-Vbeta seems a good choice.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32HG000187-01
Application #
2418087
Study Section
Genome Study Section (GNM)
Project Start
1998-03-01
Project End
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Biochemistry
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Zhu, X; McKenzie, C A; Forrester, T et al. (2000) Localization of a small genomic region associated with elevated ACE. Am J Hum Genet 67:1144-53