The object of the proposed research is to understand the roles of cadherins in hippocampal synaptogenesis. Both genetic and biochemical techniques will be used; Cadherin function will be perturbed in cultured neurons using dominant-negative constructs, and then in mouse embryos using genetic techniques. The effects of the perturbations on synaptic structure, organization and function will be examined. Secondly, we will screen for regulators of cadherin function using conventional and novel yeast-two hybrid screens. This work will shed light on the mystery of how synapses are formed and organized, and on how synapses are modulated in processes such as learning, memory, aging and diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32MH012613-01
Application #
6062412
Study Section
Special Emphasis Panel (ZRG1-MDCN-7 (02))
Program Officer
Goldschmidts, Walter L
Project Start
2000-06-01
Project End
Budget Start
2000-06-01
Budget End
2001-05-31
Support Year
1
Fiscal Year
2000
Total Cost
$32,416
Indirect Cost
Name
University of California San Francisco
Department
Physiology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143