Attention-deficit hyperactivity disorder (ADHD) is characterized by inattentiveness and/or hyperactivity and impulsiveness, placing individuals at risk for social, academic, and occupational dysfunction. Pharmacological treatments of ADHD with lowdose administration of amphetamine (AMPH)-Iike stimulants, i.e. methylphenidate, target monoaminergic neurotransmission. Virtually all information regarding actions of AMPH-like stimulants has been obtained using doses that exceed greatly those used clinically. This lack of information concerning the neural actions of therapeutically-relevant doses of methylphenidate and other AMPH-like stimulants represents a substantial lacuna in our understanding of ADHD. ? ? The proposed studies are designed to determine the effects of therapeutically-relevant doses of methylphenidate on: 1) Rates of norepinephrine/dopamine efflux; 2) Basal (tonic) and sensory driven (phasic) discharge of locus coeruleus neurons, and; 3) Cortical and subcortical neuronal circuit function. Ultimately, a better understanding of the neurochemical, cellular and network mechanisms of the therapeutic actions of these drugs is necessary for development of pharmacological treatments that do not possess the negative properties of AMPH-like stimulants. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32MH069072-02
Application #
6776924
Study Section
Special Emphasis Panel (ZRG1-F02A (20))
Program Officer
Curvey, Mary F
Project Start
2003-07-01
Project End
2006-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
2
Fiscal Year
2004
Total Cost
$47,296
Indirect Cost
Name
University of Wisconsin Madison
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Devilbiss, David M; Waterhouse, Barry D; Berridge, Craig W et al. (2012) Corticotropin-releasing factor acting at the locus coeruleus disrupts thalamic and cortical sensory-evoked responses. Neuropsychopharmacology 37:2020-30
Devilbiss, David M; Berridge, Craig W (2008) Cognition-enhancing doses of methylphenidate preferentially increase prefrontal cortex neuronal responsiveness. Biol Psychiatry 64:626-35