Understanding the neurobiological mechanisms involved in the cognitive deficits associated with externalizing behaviors (EB) has the potential to provide insight into the etiology, symptomatology, and possibilities for prevention and treatment of EB, both subclinically and in disorders such as ADHD, conduct disorder, and antisocial personality disorder. Using imaging genomics, this research will investigate the neural mechanisms involved in cognitive deficits associated with EB, such as impulsivity and aggression. I will focus on the sparing of intelligence (IQ) in individuals with a specific variant of a dopamine receptor, which I have recently discovered in my graduate work. In three samples, a specific variant of the dopamine D4 receptor gene (DRD4) completely attenuated the negative association of EB and IQ (r = .02 vs. r = -0.43). Sixty four participants, screened for the presence of relevant DRD4 variants, will be scanned with fMRI while performing cognitive and affective tasks, and will be assessed for EB, intelligence, and other individual differences. I predict that DRD4 variation will moderate brain activity within dorsolateral and ventrolateral PFC during cognitive and affective challenges, respectively. Related analyses will be done in several existing data sets. Three of these consist of children (incarcerated or diagnosed with ADHD), who have been genotyped for DRD4 polymorphisms, while a fourth consists of healthy adults with fMRI data. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32MH077382-02
Application #
7230951
Study Section
Special Emphasis Panel (ZRG1-F12B-L (20))
Program Officer
Ferrell, Courtney
Project Start
2006-04-01
Project End
2009-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
2
Fiscal Year
2007
Total Cost
$45,976
Indirect Cost
Name
Yale University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
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