The ability to attend to and """"""""select"""""""" a particular stream of input amidst those flooding our senses is a critical cognitive capacity. My broad, LONG TERM OBJECTIVE is to define the neuronal mechanisms by which the brain accomplishes this selection. The striking similarity between the rhythmic structure of many biologically- generated acoustic stimuli, such as natural speech, and of that ongoing rhythmic excitability fluctuations in the brain (i.e., neuronal oscillations) prompts my core hypothesis - that these oscillations themselves are tools that can be used to form a neural representation of the rhythmic structure of an attended stream, and that attention- enforced entrainment of neuronal oscillations is a key mechanism for sensory and perceptual selection. To evaluate these ideas, I will record electroencephalographic (EEG) signals from implanted electrodes in and surrounding auditory cortex in surgical epilepsy patients, while they engage in a series of auditory stream selection tasks. Natural speech is a prototypic example of a rhythmic biologically-generated acoustical stream, whose processing in real life situations often demands selective attention and the ability to ignore irrelevant background noises, as in the well known """"""""cocktail party"""""""" situation. Thus natural speech would be a prime example for testing my core hypothesis of attention-enforced entrainment. However this endeavor is enormously complicated by top-down phonologic, semantic and emotional influences that are also invoked during speech processing. To bypass these problems and yet get directly at the issue of attentional selection based on speech's underlying rhythmic structure, I will the use semantically meaningless sound streams, composed so as to both dissect key issues in stream selection, and mimic key aspects of rhythmic structure in speech. My FIRST SPECIFIC AIM is to define minimal rhythmic conditions for attention-enforced entrainment, and their impact on behavioral performance. I will test a fundamental proposition that attention operates in two distinct modes based on the temporal structure of the input: a """"""""rhythmic"""""""" mode, in which low frequency oscillatory entrainment to the temporal structure of the attended stream is predicted to operate as an """"""""instrument"""""""" of attentional selection, and a """"""""random"""""""" mode, in which the input stream has no detectable rhythm;in this case, I predict that low frequency oscillations will be suppressed, as they would then be a liability to stimulus discrimination. My SECOND SPECIFIC AIM is to examine selective entrainment to streams with hierarchical rhythmic structures mimicking key components of speech. Investigating neuronal oscillations as instruments of selective attention may improve our understanding of attentional dysfunction in a broad spectrum of neuropsychiatric disorders including ADHD and schizophrenia, in which affected individuals reportedly have reduced capacity to entrain neuronal oscillations to rhythmic stimuli. More directly, and perhaps more importantly, findings may also be helpful in understanding attentional deficits that are sometimes observed in epilepsy patients, which is the population participating in the proposed study.

Public Health Relevance

In this study I will study the brain mechanism involved in selectively attending to an important acoustic stimulus that occurs among other irrelevant acoustic stream, thus simulating an important real-life of situation, which is a major challenge humans are faced with regularly in daily life. I will test specific hypotheses regarding the utility of rhythmicity for attentional selection of naturalistic acoustic streams, which may have implications for understanding some of the neural defects that interfere with attention, and contribute to disorders like ADHD and schizophrenia, as well as in understanding attentional deficits that can occur in epilepsy patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32MH093061-02
Application #
8204033
Study Section
Special Emphasis Panel (ZRG1-F02B-Y (20))
Program Officer
Desmond, Nancy L
Project Start
2010-11-16
Project End
2013-11-15
Budget Start
2011-11-16
Budget End
2012-11-15
Support Year
2
Fiscal Year
2012
Total Cost
$52,190
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Noy, Niv; Bickel, Stephan; Zion-Golumbic, Elana et al. (2015) Intracranial recordings reveal transient response dynamics during information maintenance in human cerebral cortex. Hum Brain Mapp 36:3988-4003
Noy, N; Bickel, S; Zion-Golumbic, E et al. (2015) Ignition's glow: Ultra-fast spread of global cortical activity accompanying local ""ignitions"" in visual cortex during conscious visual perception. Conscious Cogn 35:206-24
Davidesco, Ido; Zion-Golumbic, Elana; Bickel, Stephan et al. (2014) Exemplar selectivity reflects perceptual similarities in the human fusiform cortex. Cereb Cortex 24:1879-93
ten Oever, Sanne; Schroeder, Charles E; Poeppel, David et al. (2014) Rhythmicity and cross-modal temporal cues facilitate detection. Neuropsychologia 63:43-50
Zion Golumbic, Elana M; Ding, Nai; Bickel, Stephan et al. (2013) Mechanisms underlying selective neuronal tracking of attended speech at a ""cocktail party"". Neuron 77:980-91
Zion Golumbic, Elana; Cogan, Gregory B; Schroeder, Charles E et al. (2013) Visual input enhances selective speech envelope tracking in auditory cortex at a ""cocktail party"". J Neurosci 33:1417-26
Zion Golumbic, Elana M; Poeppel, David; Schroeder, Charles E (2012) Temporal context in speech processing and attentional stream selection: a behavioral and neural perspective. Brain Lang 122:151-61