We propose planning for a paradigm of context based medicine, in which the basis for making evidence-based medical decisions includes not only traditional published medical knowledge but also evidence from highly processed clinical, environmental, and epidemiological information. Currently, such ambient contextual information is rarely available or at best used only informally by providers and patients making care decisions. The emerging national health information network creates an ideal opportunity for delivering context- appropriate information to decision makers, across institutions and disciplines. The goal of this proposal is to support what the NLM Long Range Plan calls a 21st century intelligent health system. The objective is to support, across Harvard healthcare institutions, inference, diagnosis and clinical prediction by formalizing a digital library infrastructure to facilitate acquisition, processing and delivery of highly processed, usable knowledge from clinical care sites, public health authorities, libraries and patients at home. We will conceptualize and plan a Contextualized Clinical Care Information Resource (C3IR) that links personal, environmental and population data to clinical and personal action by delivering interpreted and tailored information to clinicians through electronic health records and/or personally controlled health records and to individuals through personally controlled health records, at the point of decision. We will ground the planning and development process for this novel library service around four exemplary use cases. Our plan is to build a working model to serve the Harvard Medical community and cohere a learning community of institutional and individual users in the advancement, refinement and development of contextualized evidence based medicine.

Agency
National Institute of Health (NIH)
Institute
National Library of Medicine (NLM)
Type
Resources Project Grant (NLM) (G08)
Project #
3G08LM009778-01A1S1
Application #
7903651
Study Section
Special Emphasis Panel (ZLM1-ZH-C (O1))
Program Officer
Sim, Hua-Chuan
Project Start
2009-09-30
Project End
2011-09-29
Budget Start
2009-09-30
Budget End
2011-09-29
Support Year
1
Fiscal Year
2009
Total Cost
$64,288
Indirect Cost
Name
Harvard University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115
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Mandl, Kenneth D; McNabb, Marion; Marks, Norman et al. (2014) Participatory surveillance of diabetes device safety: a social media-based complement to traditional FDA reporting. J Am Med Inform Assoc 21:687-91
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Fine, Andrew M; Nizet, Victor; Mandl, Kenneth D (2013) Participatory medicine: A home score for streptococcal pharyngitis enabled by real-time biosurveillance: a cohort study. Ann Intern Med 159:577-83
Weitzman, Elissa R; Kelemen, Skyler; Quinn, Maryanne et al. (2013) Participatory surveillance of hypoglycemia and harms in an online social network. JAMA Intern Med 173:345-51
Fine, Andrew M; Nizet, Victor; Mandl, Kenneth D (2012) Large-scale validation of the Centor and McIsaac scores to predict group A streptococcal pharyngitis. Arch Intern Med 172:847-52
Dunn, A G; Bourgeois, F T; Murthy, S et al. (2012) The role and impact of research agendas on the comparative-effectiveness research among antihyperlipidemics. Clin Pharmacol Ther 91:685-91

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