The Molecular Biology Core Laboratory was established in 1995 at the Ponce School of Medicine (PSM). With the continuous support of NCRR-RCMI, this Core activity has experienced tremendous growth in capacity, number of users and has tangibly impacted upon the productivity of the research faculty in human health and health disparities at PSM, with over a 500% increase in presentations and publications citing our services in the past RCMI cycle. The MBCL will enter a new phase in this competing renewal that will continue to place major emphases on our fundamental mission to provide Access, Training, and Project Development assistance by promoting the implementation of molecular biology research in the work of both our current faculty and future recruits. As part of this next phase, our mission will expand to include greater emphasis on Service and will add new cutting edge technologies to modulate gene expression both in vitro and in vivo to complement our existing capacity to perform gene expression analyses and genetics studies. We will pursue these goals via four aims, briefly:
Aim 1 - To expand access to equipment and facilities;
Aim 2 - To provide technical/scientific support;
Aim 3 - To provide training for faculty and staff; and, Aim 4 - To actively promote the development of new projects and use of new technologies. All activities of the MBCL will be evaluated using methods to assess suitability and success in addressing the goals of this Core. In addition, a system of charge backs has been designed and begun to be implemented in order to provide for the continued institutionalization of this essential RCMI-sponsored activity. Public Statement Molecular biology is a field with tremendous capacity to advance our scientific understanding of disease and human health. Our Core facility provides a centralized source of expertise and access to sophisticated instrumentation in order to increase the productivity of the scientists at PSM so that they may more quickly make discoveries that can be translated to clinical implementation and thus have a measureable impact on improving health in the US and worldwide.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Research Centers in Minority Institutions Award (G12)
Project #
8G12MD007579-27
Application #
8573305
Study Section
Special Emphasis Panel (ZRR1-RI-1 (01))
Project Start
1997-08-25
Project End
2013-12-31
Budget Start
2012-02-02
Budget End
2012-12-31
Support Year
27
Fiscal Year
2012
Total Cost
$298,298
Indirect Cost
$101,854
Name
Ponce School of Medicine
Department
Type
DUNS #
105742043
City
Ponce
State
PR
Country
United States
Zip Code
00732
Ortiz, A P; Tamayo, V; Scorsone, A et al. (2017) Prevalence and correlates of cervical HPV infection in a clinic-based sample of HIV-positive Hispanic women. Papillomavirus Res 4:39-44
Torres-Reverón, Annelyn; Rivera, Leslie L; Flores, Idhaliz et al. (2017) Environmental Manipulations as an Effective Alternative Treatment to Reduce Endometriosis Progression. Reprod Sci :1933719117741374
Hafenbreidel, Madalyn; Rafa Todd, Carolynn; Mueller, Devin (2017) Infralimbic GluN2A-Containing NMDA Receptors Modulate Reconsolidation of Cocaine Self-Administration Memory. Neuropsychopharmacology 42:1113-1125
Cuevas, Marielly; Cruz, Myrella L; Ramirez, Antonio E et al. (2017) Stress During Development of Experimental Endometriosis Influences Nerve Growth and Disease Progression. Reprod Sci :1933719117737846
Martínez-Rivera, Freddyson J; Pérez-Laspiur, Juliana; Santiago-Gascot, María E et al. (2017) Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids. PLoS One 12:e0180409
Criado-Marrero, Marangelie; Morales Silva, Roberto J; Velazquez, Bethzaly et al. (2017) Dynamic expression of FKBP5 in the medial prefrontal cortex regulates resiliency to conditioned fear. Learn Mem 24:145-152
Hernandez, Siomara; Cruz, Myrella L; Seguinot, Inevy I et al. (2017) Impact of Psychological Stress on Pain Perception in an Animal Model of Endometriosis. Reprod Sci 24:1371-1381
Castro, Eida M; Asencio, Gloria; Quinn, Gwendolyn P et al. (2017) Importance of and Satisfaction with Psychosocial Support among Cancer Patients and Survivors in Puerto Rico: Gender, Health Status, and Quality of Life Associations. P R Health Sci J 36:205-211
Ramos-Ortolaza, Dinah L; Doreste-Mendez, Raura J; Alvarado-Torres, John K et al. (2017) Ovarian hormones modify anxiety behavior and glucocorticoid receptors after chronic social isolation stress. Behav Brain Res 328:115-122
Abreu-Delgado, Yamilka; Isidro, Raymond A; Torres, Esther A et al. (2016) Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease. World J Gastroenterol 22:3581-91

Showing the most recent 10 out of 89 publications