The Molecular Biology Core Laboratory was established in 1995 at the Ponce School of Medicine (PSM). With the continuous support of NCRR-RCMI, this Core activity has experienced tremendous growth in capacity, number of users and has tangibly impacted upon the productivity of the research faculty in human health and health disparities at PSM, with over a 500% increase in presentations and publications citing our services in the past RCMI cycle. The MBCL will enter a new phase in this competing renewal that will continue to place major emphases on our fundamental mission to provide Access, Training, and Project Development assistance by promoting the implementation of molecular biology research in the work of both our current faculty and future recruits. As part of this next phase, our mission will expand to include greater emphasis on Service and will add new cutting edge technologies to modulate gene expression both in vitro and in vivo to complement our existing capacity to perform gene expression analyses and genetics studies. We will pursue these goals via four aims, briefly:
Aim 1 - To expand access to equipment and facilities;
Aim 2 - To provide technical/scientific support;
Aim 3 - To provide training for faculty and staff; and, Aim 4 - To actively promote the development of new projects and use of new technologies. All activities of the MBCL will be evaluated using methods to assess suitability and success in addressing the goals of this Core. In addition, a system of charge backs has been designed and begun to be implemented in order to provide for the continued institutionalization of this essential RCMI-sponsored activity. Public Statement Molecular biology is a field with tremendous capacity to advance our scientific understanding of disease and human health. Our Core facility provides a centralized source of expertise and access to sophisticated instrumentation in order to increase the productivity of the scientists at PSM so that they may more quickly make discoveries that can be translated to clinical implementation and thus have a measureable impact on improving health in the US and worldwide.
| King, Jamie L; Zhang, Baotong; Li, Yixiang et al. (2018) TTK promotes mesenchymal signaling via multiple mechanisms in triple negative breast cancer. Oncogenesis 7:69 |
| López, Pablo; De Jesús, Omayra; Yamamura, Yasuhiro et al. (2018) Molecular Epidemiology of HIV-1 Virus in Puerto Rico: Novel Cases of HIV-1 Subtype C, D, and CRF-24BG. AIDS Res Hum Retroviruses 34:507-516 |
| Torres-Reverón, Annelyn; Rivera, Leslie L; Flores, Idhaliz et al. (2018) Environmental Manipulations as an Effective Alternative Treatment to Reduce Endometriosis Progression. Reprod Sci 25:1336-1348 |
| Diaz-Zabala, Hector J; Ortiz, Ana P; Garland, Lisa et al. (2018) A Recurrent BRCA2 Mutation Explains the Majority of Hereditary Breast and Ovarian Cancer Syndrome Cases in Puerto Rico. Cancers (Basel) 10: |
| Lee, Miyoung; Gudas, Lorraine J; Saavedra, Harold I (2018) Detection of E2F-DNA Complexes Using Chromatin Immunoprecipitation Assays. Methods Mol Biol 1726:143-151 |
| Cuevas, Marielly; Cruz, Myrella L; Ramirez, Antonio E et al. (2018) Stress During Development of Experimental Endometriosis Influences Nerve Growth and Disease Progression. Reprod Sci 25:347-357 |
| Arias, Andrea; López, Pablo; Sánchez, Raphael et al. (2018) Sanger and Next Generation Sequencing Approaches to Evaluate HIV-1 Virus in Blood Compartments. Int J Environ Res Public Health 15: |
| Doncheck, Elizabeth M; Hafenbreidel, Madalyn; Ruder, Sarah A et al. (2018) bFGF expression is differentially regulated by cocaine seeking versus extinction in learning-related brain regions. Learn Mem 25:361-368 |
| Rivera-Segarra, Eliut; Rosario-Hernández, Ernesto; Carminelli-Corretjer, Paola et al. (2018) Suicide Stigma among Medical Students in Puerto Rico. Int J Environ Res Public Health 15: |
| Allen, Julie K; Armaiz-Pena, Guillermo N; Nagaraja, Archana S et al. (2018) Sustained Adrenergic Signaling Promotes Intratumoral Innervation through BDNF Induction. Cancer Res 78:3233-3242 |
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