In 2004, CCRTD decided to focus on building a nationally recognized program in prostate cancer research, education and community service. Since then, we have actively recruited prostate cancer experts to CCRTD and Clark Atlanta University in the past seven years. We have recruited two new faculty members in the Department of Biological Sciences between 2004-2007 and an additional three junior faculty members with interests in prostate cancer research between 2007-2012. In this proposal we are requesting partial support for the recruitment of three new faculty; two Assistant Professors and one Associate Professor. The faculty will be added one each in 2014, 2015 and 2016. After several discussions among the current CCRTD scientists and with the Institutional Advisory Committee, it was decided that the expertise is needed in the following areas: 1. Prostate cancer in vivo biology 2. Epidemiology of prostate cancer in minority populations 3. Cell and developmental biology 4. Prostate cancer health disparities 5. Therapeutics The new hires will increase capacity, add diversity of research areas and training mentors and open new teaching and learning avenues for graduate and undergraduate African American students. The completed team should provide a greater reach and depth to understand molecular biology of prostate cancer in relation to racial disparities and incidence at the bench and the community level.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12MD007590-30
Application #
9447509
Study Section
Special Emphasis Panel (ZMD1-MLS (01))
Program Officer
Das, Rina
Project Start
Project End
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
30
Fiscal Year
2017
Total Cost
$78,637
Indirect Cost
$112,224
Name
Clark Atlanta University
Department
Type
Domestic Higher Education
DUNS #
065325177
City
Atlanta
State
GA
Country
United States
Zip Code
30314
George, Alex; Raji, Idris; Cinar, Bekir et al. (2018) Design, synthesis, and evaluation of the antiproliferative activity of hydantoin-derived antiandrogen-genistein conjugates. Bioorg Med Chem 26:1481-1487
Hawsawi, Ohuod; Henderson, Veronica; Burton, Liza J et al. (2018) High mobility group A2 (HMGA2) promotes EMT via MAPK pathway in prostate cancer. Biochem Biophys Res Commun 504:196-202
Elliott, Bethtrice; Zackery, DeAdra L; Eaton, Vanessa A et al. (2018) Ethnic differences in TGF?-signaling pathway may contribute to prostate cancer health disparity. Carcinogenesis 39:546-555
Kimbrough-Allah, Mawiyah N; Millena, Ana C; Khan, Shafiq A (2018) Differential role of PTEN in transforming growth factor ? (TGF-?) effects on proliferation and migration in prostate cancer cells. Prostate 78:377-389
Dang, Tu; Liou, Geou-Yarh (2018) Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt. Sci Rep 8:7718
Scarlett, Kisha A; White, El-Shaddai Z; Coke, Christopher J et al. (2018) Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits G?13/RhoA-mediated Migration. Mol Cancer Res 16:728-739
Caggia, Silvia; Chunduri, HimaBindu; Millena, Ana C et al. (2018) Novel role of Gi?2 in cell migration: Downstream of PI3-kinase-AKT and Rac1 in prostate cancer cells. J Cell Physiol 234:802-815
Liou, Geou-Yarh (2017) Inflammatory Cytokine Signaling during Development of Pancreatic and Prostate Cancers. J Immunol Res 2017:7979637
Burton, Liza J; Henderson, Veronica; Liburd, Latiffa et al. (2017) Snail transcription factor NLS and importin ?1 regulate the subcellular localization of Cathepsin L and Cux1. Biochem Biophys Res Commun 491:59-64
Rivera, Mariela; Ramos, Yanilda; Rodríguez-Valentín, Madeline et al. (2017) Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells. PLoS One 12:e0179587

Showing the most recent 10 out of 67 publications