The University of Texas at El Paso (UTEP) proposes to enhance basic and translational research on pathologies prevalent in the Hispanic-majority population along the United States border with Mexico. Specifically, UTEP seeks to increase the productivity and capacity of its Border Biomedical Research Center (BBRC) to promote new discoveries and apply them to benefit health and education in this region and the nation as a whole. To accomplish this, the institution has assigned priority for research in (1) infectious diseases and immunology, (2) toxicology, and (3) neuroscience and metabolic disorders, major research thrusts of the BBRC. The BBRC's research team has been expanded with faculty acquisitions in Biological Sciences, Chemistry, Physics, Psychology, and the College of Health Sciences. Commitments of support have been obtained from external research centers, such as the national laboratories at the University of Texas Medical Branch in Galveston. A new Biosciences research facility has been built on campus, and houses BBRC Core labs in Cell Culture and High Throughput Screening, DNA Analysis, Analytical Cytology, Biomolecule Anlaysis, Bioinformatics and Statistical Consulting. These Core resources are being used to attract additional talent that will contribute to the biomedical research program. The developing scientific competitiveness of BBRC investigators is evident in the increased number of R-01 grants funded, from 0 to 6, in the last three years alone. The BBRC provides a strong research infrastructure for undergraduate, graduate and postdoctoral training. Thus, through this key RCMI-supported program, UTEP is realizing an institutional goal of serving as a major point of entry for underrepresented minorities into the biomedical research mainstream of the nation. As partial evidence of progress in this area, UTEP has increased its Ph.D. graduates in biology from 0 to 14 in this past RCMI funding cycle. Through significant RCMI support and a strong institutional commitment to the BBRC, and through the productivity and collaborations of this Center, UTEP is establising itself as a leading regional research entity and is gaining national and international recognition for its biomedical research and training resources and capabilities.

Public Health Relevance

The overall goal of the RCMI-Border Biomedical Research Center is to promote and enable quality biomedical research on the pathologies of major health problems prevalent on the U.S.-Mexican border and provide opportunities for Hispanics and other underrepresented minorities entry into the biomedical research mainstream of the nation.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Research Centers in Minority Institutions Award (G12)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Program Officer
Sayre, Michael
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas El Paso
Schools of Arts and Sciences
El Paso
United States
Zip Code
Nunes, Larissa M; Hossain, Mohammad; Varela-Ramirez, Armando et al. (2016) A novel class of piperidones exhibit potent, selective and pro-apoptotic anti-leukemia properties. Oncol Lett 11:3842-3848
Dai, Liping; Peng, Xuan-Xian; Tan, Eng M et al. (2016) Tumor-associated antigen CAPERα and microvessel density in hepatocellular carcinoma. Oncotarget 7:16985-95
Szempruch, Anthony J; Sykes, Steven E; Kieft, Rudo et al. (2016) Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia. Cell 164:246-57
Medina, Maria F; Bauer, Aaron M; Branch, William R et al. (2016) Molecular phylogeny of Panaspis and Afroablepharus skinks (Squamata: Scincidae) in the savannas of sub-Saharan Africa. Mol Phylogenet Evol 100:409-23
Duarte, Trevor T; Spencer, Charles T (2016) Personalized Proteomics: The Future of Precision Medicine. Proteomes 4:
Zhang, Qi; Wang, Decheng; Jiang, Guozhong et al. (2016) EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5. Sci Rep 6:32618
Liang, Su; Bian, Xiaomei; Liang, Dong et al. (2016) Solution formulation development and efficacy of MJC13 in a preclinical model of castration-resistant prostate cancer. Pharm Dev Technol 21:121-6
Robles-Escajeda, Elisa; Das, Umashankar; Ortega, Nora M et al. (2016) A novel curcumin-like dienone induces apoptosis in triple-negative breast cancer cells. Cell Oncol (Dordr) 39:265-77
D'Arcy, Christina; Luevano, Joe E; Miranda-Arango, Manuel et al. (2016) Extended access to methamphetamine self-administration up-regulates dopamine transporter levels 72 hours after withdrawal in rats. Behav Brain Res 296:125-8
Su, Xiaogang; Wijayasinghe, Chalani S; Fan, Juanjuan et al. (2016) Sparse estimation of Cox proportional hazards models via approximated information criteria. Biometrics 72:751-9

Showing the most recent 10 out of 147 publications