The University of Texas at El Paso (UTEP) proposes to enhance basic and translational research on pathologies prevalent in the Hispanic-majority population along the United States border with Mexico. Specifically, UTEP seeks to increase the productivity and capacity of its Border Biomedical Research Center (BBRC) to promote new discoveries and apply them to benefit health and education in this region and the nation as a whole. To accomplish this, the institution has assigned priority for research in (1) infectious diseases and immunology, (2) toxicology, and (3) neuroscience and metabolic disorders, major research thrusts of the BBRC. The BBRC's research team has been expanded with faculty acquisitions in Biological Sciences, Chemistry, Physics, Psychology, and the College of Health Sciences. Commitments of support have been obtained from external research centers, such as the national laboratories at the University of Texas Medical Branch in Galveston. A new Biosciences research facility has been built on campus, and houses BBRC Core labs in Cell Culture and High Throughput Screening, DNA Analysis, Analytical Cytology, Biomolecule Anlaysis, Bioinformatics and Statistical Consulting. These Core resources are being used to attract additional talent that will contribute to the biomedical research program. The developing scientific competitiveness of BBRC investigators is evident in the increased number of R-01 grants funded, from 0 to 6, in the last three years alone. The BBRC provides a strong research infrastructure for undergraduate, graduate and postdoctoral training. Thus, through this key RCMI-supported program, UTEP is realizing an institutional goal of serving as a major point of entry for underrepresented minorities into the biomedical research mainstream of the nation. As partial evidence of progress in this area, UTEP has increased its Ph.D. graduates in biology from 0 to 14 in this past RCMI funding cycle. Through significant RCMI support and a strong institutional commitment to the BBRC, and through the productivity and collaborations of this Center, UTEP is establising itself as a leading regional research entity and is gaining national and international recognition for its biomedical research and training resources and capabilities.

Public Health Relevance

The overall goal of the RCMI-Border Biomedical Research Center is to promote and enable quality biomedical research on the pathologies of major health problems prevalent on the U.S.-Mexican border and provide opportunities for Hispanics and other underrepresented minorities entry into the biomedical research mainstream of the nation.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Research Centers in Minority Institutions Award (G12)
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Special Emphasis Panel (ZRR1-RI-B (01))
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Sayre, Michael
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University of Texas El Paso
Schools of Arts and Sciences
El Paso
United States
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Liu, Xinxin; Chai, Yurong; Li, Jitian et al. (2014) Autoantibody response to a novel tumor-associated antigen p90/CIP2A in breast cancer immunodiagnosis. Tumour Biol 35:2661-7
Rico, Cyren M; Lee, Sang Chul; Rubenecia, Rosnah et al. (2014) Cerium oxide nanoparticles impact yield and modify nutritional parameters in wheat (Triticum aestivum L.). J Agric Food Chem 62:9669-75
Gant Jr, Vincent U; Moreno, Stephanie; Varela-Ramirez, Armando et al. (2014) Two membrane-associated regions within the Nodamura virus RNA-dependent RNA polymerase are critical for both mitochondrial localization and RNA replication. J Virol 88:5912-26
Liu, Mei; Zheng, Su-jun; Chen, Yu et al. (2014) Autoantibody response to murine double minute 2 protein in immunodiagnosis of hepatocellular carcinoma. J Immunol Res 2014:906532
Mariano, Vania Sammartino; Zorzetto-Fernandes, Andre Luiz; da Silva, Thiago Aparecido et al. (2014) Recognition of TLR2 N-glycans: critical role in ArtinM immunomodulatory activity. PLoS One 9:e98512
Roy, Debarshi; Kabiraj, Parijat; Pal, Rituraj (2014) EF24 prevents rotenone-induced estrogenic status alteration in breast cancer. Cell Biol Int 38:511-9
Liu, Mei; Liu, Xinxin; Ren, Pengfei et al. (2014) A cancer-related protein 14-3-3? is a potential tumor-associated antigen in immunodiagnosis of hepatocellular carcinoma. Tumour Biol 35:4247-56
Dai, Liping; Li, Jitian; Ortega, Rosalia et al. (2014) Preferential autoimmune response in prostate cancer to cyclin B1 in a panel of tumor-associated antigens. J Immunol Res 2014:827827
Liu, Xinxin; Ye, Hua; Li, Liuxia et al. (2014) Humoral autoimmune responses to insulin-like growth factor II mRNA-binding proteins IMP1 and p62/IMP2 in ovarian cancer. J Immunol Res 2014:326593
Chai, Yurong; Liu, Xinxin; Dai, Liping et al. (2014) Overexpression of HCC1/CAPER? may play a role in lung cancer carcinogenesis. Tumour Biol 35:6311-7

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