As the principal U.S. institution of higher education engaged in biomedical and bio-behavioral research within the Pacific basin, the University of Hawaii at Manoa (UHM) seeks continued support from the Research Centers in Minority Institutions (RCMI) Program of the National Institutes of Health, to further develop research excellence in biomedicine by establishing an interdisciplinary network aimed at linking basic sciences, clinical medicine and translational research discoveries, with the goal of Attain Lasting Optimal Health for All (ALOHA), and with specific emphasis on addressing health disparities in underserved minority populations. Designated the Bioscience Research Infrastructure Development for Grant Enhancement and Success (BRIDGES), the UHM RCMI Program for the 2012-2017 cycle will embrace the spirit and tenets of the NIH Roadmap by creating interdisciplinary collaborative research networks employing emerging technologies for basic, clinical and translational sciences. Specifically, the research activities focusing on Collaborations and Partnerships and Professional Development, and the infrastructure cores in proteomics, magnetic resonance imaging, electrophysiology and behavior, microscopy, histopathology, human tissue biorepositories, bioinformatics, biostatistics and research ethics will rely heavily on interdisciplinary collaborations and intellectual exchange between basic scientists and clinicians, applying knowledge of human biology, physiology, biochemistry, molecular biology and fundamental principles of physics and chemistry, to develop novel and improved disease-specific diagnostic tests, therapeutic interventions and preventive strategies for health disparities of regional and national importance. These activities are designed to closely complement the basic science, clinical and patient-oriented activities of the RCMI Clinical Translational Research Center, (RCTR RMATRIX), the Center for Native and Pacific Health Disparities Research (CNPHDR), the Hawaii Statewide Research and Education Partnership (INBRE HSREP), and the Centers of Biomedical Research Excellence (COBRE). The RCMI BRIDGES Program will better position UHM to participate fully in the RCMI Translational Research Network and to ultimately secure a Clinical and Translational Sciences Award. Strong leadership has been identified for each of the Activities and Cores. Finally, complementary technical cores are being developed and expanded to achieve greater success in competing for mainstream extramural NIH funding for research and training.

Public Health Relevance

The overall objectives of the RCMI Program at UHM are to create and strengthen expertise, education, training and infrastructure for biomedical and behavioral research that promises to improve the diagnosis, prevention, and treatment of diseases, especially those associated with health disparities in minority populations in Hawaii.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Research Centers in Minority Institutions Award (G12)
Project #
8G12MD007601-27
Application #
8334067
Study Section
Special Emphasis Panel (ZRR1-RI-B (02))
Program Officer
Cooper, Leslie
Project Start
1997-09-01
Project End
2016-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
27
Fiscal Year
2012
Total Cost
$2,592,349
Indirect Cost
$864,116
Name
University of Hawaii
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Terada, Keith Y; Ahn, Hyeong Jun; Kessel, Bruce (2016) Differences in risk for type 1 and type 2 ovarian cancer in a large cancer screening trial. J Gynecol Oncol 27:e25
Wey, Andrew; Vock, David M; Connett, John et al. (2016) Estimating restricted mean treatment effects with stacked survival models. Stat Med 35:3319-32
Terada, Keith; Carney, Michael; Kim, Robert et al. (2016) Health Disparities in Native Hawaiians and Other Pacific Islanders Following Hysterectomy for Endometrial Cancer. Hawaii J Med Public Health 75:137-9
Mitchell, Brooks I; Byron, Mary Margaret; Ng, Roland C et al. (2016) Elevation of Non-Classical (CD14+/lowCD16++) Monocytes Is Associated with Increased Albuminuria and Urine TGF-β1 in HIV-Infected Individuals on Stable Antiretroviral Therapy. PLoS One 11:e0153758
Douet, Vanessa; Tanizaki, Naomi; Franke, Adrian et al. (2016) Polymorphism of Kynurenine Pathway-Related Genes, Kynurenic Acid, and Psychopathological Symptoms in HIV. J Neuroimmune Pharmacol 11:549-61
Wolforth, Lynne Mackin; Loo, Sherry W; Sood, Sneha L (2016) Retinopathy of Prematurity and Ethnicity in Hawai'i: A Retrospective Study (1996 - 2006) of Medical Records from Kapi'olani Medical Center for Women and Children. Hawaii J Med Public Health 75:68-72
Pang, Xiaosha; Panee, Jun (2016) Anti-inflammatory Function of Phyllostachys Edulis Extract in the Hippocampus of HIV-1 Transgenic Rats. J HIV AIDS 2:
Chow, Dominic C; Kagihara, Jamie M; Zhang, Guangxiang et al. (2016) Non-classical monocytes predict progression of carotid artery bifurcation intima-media thickness in HIV-infected individuals on stable antiretroviral therapy. HIV Clin Trials 17:114-22
Rougée, Luc R A; Riches, Zoe; Berman, Jacob M et al. (2016) The Ontogeny and Population Variability of Human Hepatic NADPH Dehydrogenase Quinone Oxido-Reductase 1 (NQO1). Drug Metab Dispos 44:967-74
Campbell, Janis; Gandhi, Krupa; Pate, Anne et al. (2016) Five-Year Cancer Survival Rates in Oklahoma from 1997 to 2008. J Okla State Med Assoc 109:318-332

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