As the principal U.S. institution of higher education engaged in biomedical and bio-behavioral research within the Pacific basin, the University of Hawaii at Manoa (UHM) seeks continued support from the Research Centers in Minority Institutions (RCMI) Program of the National Institutes of Health, to further develop research excellence in biomedicine by establishing an interdisciplinary network aimed at linking basic sciences, clinical medicine and translational research discoveries, with the goal of Attain Lasting Optimal Health for All (ALOHA), and with specific emphasis on addressing health disparities in underserved minority populations. Designated the Bioscience Research Infrastructure Development for Grant Enhancement and Success (BRIDGES), the UHM RCMI Program for the 2012-2017 cycle will embrace the spirit and tenets of the NIH Roadmap by creating interdisciplinary collaborative research networks employing emerging technologies for basic, clinical and translational sciences. Specifically, the research activities focusing on Collaborations and Partnerships and Professional Development, and the infrastructure cores in proteomics, magnetic resonance imaging, electrophysiology and behavior, microscopy, histopathology, human tissue biorepositories, bioinformatics, biostatistics and research ethics will rely heavily on interdisciplinary collaborations and intellectual exchange between basic scientists and clinicians, applying knowledge of human biology, physiology, biochemistry, molecular biology and fundamental principles of physics and chemistry, to develop novel and improved disease-specific diagnostic tests, therapeutic interventions and preventive strategies for health disparities of regional and national importance. These activities are designed to closely complement the basic science, clinical and patient-oriented activities of the RCMI Clinical Translational Research Center, (RCTR RMATRIX), the Center for Native and Pacific Health Disparities Research (CNPHDR), the Hawaii Statewide Research and Education Partnership (INBRE HSREP), and the Centers of Biomedical Research Excellence (COBRE). The RCMI BRIDGES Program will better position UHM to participate fully in the RCMI Translational Research Network and to ultimately secure a Clinical and Translational Sciences Award. Strong leadership has been identified for each of the Activities and Cores. Finally, complementary technical cores are being developed and expanded to achieve greater success in competing for mainstream extramural NIH funding for research and training.

Public Health Relevance

The overall objectives of the RCMI Program at UHM are to create and strengthen expertise, education, training and infrastructure for biomedical and behavioral research that promises to improve the diagnosis, prevention, and treatment of diseases, especially those associated with health disparities in minority populations in Hawaii.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12MD007601-29
Application #
8716564
Study Section
Special Emphasis Panel (ZRR1)
Program Officer
Wasserman, Joan
Project Start
1997-09-01
Project End
2016-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
29
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Hawaii
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Liang, Huajun; Chang, Linda; Chen, Rong et al. (2018) Independent and Combined Effects of Chronic HIV-Infection and Tobacco Smoking on Brain Microstructure. J Neuroimmune Pharmacol 13:509-522
Marciel, Michael P; Rose, Aaron H; Martinez, Verena et al. (2018) Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme. Cancer Med 7:175-183
Hulgan, Todd; Ramsey, Benjamin S; Koethe, John R et al. (2018) Relationships between Adipose Mitochondrial Function, Serum Adiponectin, and Insulin Resistance in Persons with HIV after 96 weeks of Antiretroviral Therapy. J Acquir Immune Defic Syndr :
Pitts, Matthew W (2018) Barnes Maze Procedure for Spatial Learning and Memory in Mice. Bio Protoc 8:
Seale, Lucia A; Ogawa-Wong, Ashley N; Berry, Marla J (2018) SEXUAL DIMORPHISM IN SELENIUM METABOLISM AND SELENOPROTEINS. Free Radic Biol Med 127:198-205
Gandhi, Krupa; Lim, Eunjung; Davis, James et al. (2018) Racial Disparities in Health Service Utilization Among Medicare Fee-for-Service Beneficiaries Adjusting for Multiple Chronic Conditions. J Aging Health 30:1224-1243
Hendrickson, Marissa A; Wey, Andrew R; Gaillard, Philippe R et al. (2018) Implementation of an Electronic Clinical Decision Support Tool for Pediatric Appendicitis Within a Hospital Network. Pediatr Emerg Care 34:10-16
D'Antoni, Michelle L; Byron, Mary Margaret; Chan, Phillip et al. (2018) Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities. J Infect Dis 218:1453-1463
Aquino, Rachael K; Perez, Michael; Sil, Payel et al. (2018) The Relationship of 5-Aminolevulinic Acid on Mood and Coping Ability in Prediabetic Middle Aged and Older Adults. Geriatrics (Basel) 3:
Marciel, Michael P; Khadka, Vedbar S; Deng, Youpeng et al. (2018) Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget 9:13407-13422

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