This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff.
Specific Aims The overall goal of this project remains the same and is to elucidate the regulatory mechanism(s) and functional consequences of cytochorme P450 (CYP) epoxygenase metabolites (EETs) in the development and progression of vascular and renal dysfunction related to diabetic metabolic syndrome. Experiments performed over the project period have resulted in significant progress on the three Specific Aims. In addition, we have expanded our recent studies to determine glomerular epithelial injury in progressive diabetic nephropathy.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
2G12RR003034-26
Application #
8357157
Study Section
Special Emphasis Panel (ZRR1-RI-B (02))
Project Start
2011-09-19
Project End
2012-06-30
Budget Start
2011-09-19
Budget End
2012-06-30
Support Year
26
Fiscal Year
2011
Total Cost
$94,934
Indirect Cost
Name
Morehouse School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
102005451
City
Atlanta
State
GA
Country
United States
Zip Code
30310
Chowdhury, Indrajit; Branch, Alicia; Mehrabi, Sharifeh et al. (2017) Gonadotropin-Dependent Neuregulin-1 Signaling Regulates Female Rat Ovarian Granulosa Cell Survival. Endocrinology 158:3647-3660
Huang, Ming-Bo; Gonzalez, Ruben R; Lillard, James et al. (2017) Secretion modification region-derived peptide blocks exosome release and mediates cell cycle arrest in breast cancer cells. Oncotarget 8:11302-11315
Sánchez-Bretaño, Aída; Baba, Kenkichi; Janjua, Uzair et al. (2017) Melatonin partially protects 661W cells from H2O2-induced death by inhibiting Fas/FasL-caspase-3. Mol Vis 23:844-852
Laurent, Virgine; Sengupta, Anamika; Sánchez-Bretaño, Aída et al. (2017) Melatonin signaling affects the timing in the daily rhythm of phagocytic activity by the retinal pigment epithelium. Exp Eye Res 165:90-95
Tchio Mantho, Cynthia I; Harbuzariu, Adriana; Gonzalez-Perez, Ruben R (2017) Histone deacetylases, microRNA and leptin crosstalk in pancreatic cancer. World J Clin Oncol 8:178-189
Harmon, Tia; Harbuzariu, Adriana; Lanier, Viola et al. (2017) Nanoparticle-linked antagonist for leptin signaling inhibition in breast cancer. World J Clin Oncol 8:54-66
Inoue, Koichi; Leng, Tiandong; Yang, Tao et al. (2016) Role of serum- and glucocorticoid-inducible kinases in stroke. J Neurochem 138:354-61
Kang, Ting; Jones, Tia M; Naddell, Clayton et al. (2016) Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31. Stem Cells Transl Med 5:440-50
Li, Wenzhi; Xu, Wei; He, Shaohua et al. (2016) Data supporting the high-accuracy haplotype imputation using unphased genotype data as the references. Data Brief 8:1412-5
Simmons, Lauren J; Surles-Zeigler, Monique C; Li, Yonggang et al. (2016) Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway. J Neuroinflammation 13:237

Showing the most recent 10 out of 281 publications