This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Deciphering the pathways of host invasion is crucial to understanding malaria, one of the world's deadliest infectious diseases. Malaria is a parasitic human disease caused by four different species of Plasmodium: P. falciparum, P. vivax, P. malariae, and P. ovale. Humans have many genetic adaptations that fight malaria, such as the sickle-cell allele. This pilot project specifically examines malarial adaptation at the band 3 (SLC4A1) and the glycophorin A (GYPA) genes, which are both implicated in human resistance to malaria, specifically aspects of the disease associated with P. falciparum malaria. This project will examine DNA sequences of non-human primates to test hypotheses of the Plasmodium specificity of the genetic adaptations at SLC4A1 and GYPA to human P. falciparum. These hypotheses will be tested by pursuing the following Specific Aim. SLC4A1 and GYPA will be compared among non-human primates, to test to adaptive genetic in species which harbor and are resistant to different species of Plasmodium. Non-human primates provide unique and compelling models for understanding the genetic basis of many human diseases, including malaria. This project will join our current understanding of human and primate malaria to bioinformatics and evolutionary analyses in order to test for the parasite specificity of human adaptations to malaria. Determining the parasite specificity of human genetic adaptations to malaria is significant because it will help to detail the different pathways each parasite utilizes to infect humans, in turn yielding targets for the disruption of the infection process. Furthermore, comparative analysis of primate-Plasmodium interactions is also critical for development of the most realistic animals models for studying human malaria. This research will also help to understand a disease that was a major health issue for many Americans prior to 1940. The pilot project will make strides in pursuing the long-term research goal of a comparative understanding of how infectious diseases have shaped the genomes of humans and other primates.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
2G12RR003037-26A1
Application #
8357181
Study Section
Special Emphasis Panel (ZRR1-RI-B (02))
Project Start
2011-09-15
Project End
2012-06-30
Budget Start
2011-09-15
Budget End
2012-06-30
Support Year
26
Fiscal Year
2011
Total Cost
$123,881
Indirect Cost
Name
Hunter College
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
620127915
City
New York
State
NY
Country
United States
Zip Code
10065
Avila, Jorge A; Alliger, Amber A; Carvajal, Brigett et al. (2017) Estradiol rapidly increases GluA2-mushroom spines and decreases GluA2-filopodia spines in hippocampus CA1. Hippocampus 27:1224-1229
Kiprowska, Magdalena J; Stepanova, Anna; Todaro, Dustin R et al. (2017) Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. Biochim Biophys Acta 1863:1157-1170
Babkirk, Sarah; Luehring-Jones, Peter; Dennis-Tiwary, Tracy A (2016) Computer-mediated communication preferences predict biobehavioral measures of social-emotional functioning. Soc Neurosci 11:637-51
Urbanski, Mateusz M; Kingsbury, Lyle; Moussouros, Daniel et al. (2016) Myelinating glia differentiation is regulated by extracellular matrix elasticity. Sci Rep 6:33751
He, Huifang; Deng, Kangwen; Siddiq, Mustafa M et al. (2016) Cyclic AMP and Polyamines Overcome Inhibition by Myelin-Associated Glycoprotein through eIF5A-Mediated Increases in p35 Expression and Activation of Cdk5. J Neurosci 36:3079-91
Carbone, Lorenzo; Verrelli, Roberta; Gobet, Mallory et al. (2016) Insight on the Li2S electrochemical process in a composite configuration electrode. New J Chem 40:2935-2943
IƱiguez, Sergio D; Aubry, Antonio; Riggs, Lace M et al. (2016) Social defeat stress induces depression-like behavior and alters spine morphology in the hippocampus of adolescent male C57BL/6 mice. Neurobiol Stress 5:54-64
Yoon, Seungyeon A; Weierich, Mariann R (2016) Salivary biomarkers of neural hypervigilance in trauma-exposed women. Psychoneuroendocrinology 63:17-25
Oliver, Chicora F; Kabitzke, Patricia; Serrano, Peter et al. (2016) Repeated recall and PKM? maintain fear memories in juvenile rats. Learn Mem 23:710-713
Jacome, Luis F; Barateli, Ketti; Buitrago, Dina et al. (2016) Gonadal Hormones Rapidly Enhance Spatial Memory and Increase Hippocampal Spine Density in Male Rats. Endocrinology 157:1357-62

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