PROJECT 2:TOXICOLOGY Program Director/Principal Investigator (Last, First, Middle): Natalicio, Diana S./Kirken, Robert 1. Introduction to Resubmission Application This is the revised version of an application that was rated """"""""Good"""""""" in the first review cycle. We appreciate the reviewer's helpful comments and suggestions and have addressed the majority of the concerns throughout this proposal. One of the major criticisms was the lack of a detailed plan for the expansion of translational research by the Project. One specific example of a new initiative with translational potential is outlined in Section 5.2.2 as well as a directed hire in pharmacology or molecular toxicology. The second major criticism was the lack of needed equipment on-site for analyzing water samples for Pharmaceuticals and personal care product derivatives. Please see the description of the GC MS capabilities described under Core B which should be more than sufficient for most applications, for the remainder a budget item has been included to send the samples out for additional analyses. Other criticisms are addressed in the following narrative. The Toxicology Project (TOXP) is one of the three broad research groups within the BBRC, along with the Infectious Disease and Immunology Project (IDIP) and Neurology and Metabolic Disorders (see Figure 1 below). TOXP promotes and fosters collaboration among Pis within the Project, among Projects, with other Departments at UTEP as well as with investigators located outside of UTEP. As outlined in detail below, TOXP actively supports the basic research into environmental, human and animal health issues as they relate to the discipline of Toxicology. Key or crucial issues along the U.S.-Mexico border are: heavy metal contamination and exposure, water pollution from both domestic and international sources, air pollution and the associated acute and chronic exposure to the environmental contaminants originating from the deposition of a suite of small molecules that pollute the air. TOXP research expertise and access to highly specialized equipment allows us to engage in state of the art research in these areas. TOXP promotes and supports dissemination of research findings by supporting travel to local, regional, national and international conferences. Aside from supporting participation at professional meetings, TOXP provides funds for participation in other professional development opportunities such as attendance to specialized workshops. TOXP's research agenda is well integrated with IDIP and NMDP. Collaborative efforts among our research groups are described below in Section 4.2. This overall mission enhances our current Toxicology research efforts and increases the future competitiveness of our investigators toward securing extramural funding for student and community education in addition to hypothesis- and need-driven research into environmental pollution issues along the U.S.-Mexico border.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR008124-18
Application #
8357076
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Project Start
2011-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
18
Fiscal Year
2011
Total Cost
$235,134
Indirect Cost
Name
University of Texas El Paso
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
132051285
City
El Paso
State
TX
Country
United States
Zip Code
79968
Sobin, Christina; Flores-Montoya, Mayra Gisel; Alvarez, Juan Manuel (2017) Early chronic low-level Pb exposure alters global exploratory behaviors but does not impair spatial and object memory retrieval in an object-in-place task in pre-adolescent C57BL/6J mice. Neurotoxicol Teratol 61:104-114
Aranda, Gissel P; Hinojos, Samantha J; Sabandal, Paul R et al. (2017) Behavioral Sensitization to the Disinhibition Effect of Ethanol Requires the Dopamine/Ecdysone Receptor in Drosophila. Front Syst Neurosci 11:56
Montoya, Alexa; Amaya, Clarissa N; Belmont, Andres et al. (2017) Use of non-selective ?-blockers is associated with decreased tumor proliferative indices in early stage breast cancer. Oncotarget 8:6446-6460
Del Rio, Michelle; Alvarez, Juan; Mayorga, Tania et al. (2017) A comparison of arsenic exposure in young children and home water arsenic in two rural West Texas communities. BMC Public Health 17:850
Iniguez, Eva; Schocker, Nathaniel S; Subramaniam, Krishanthi et al. (2017) An ?-Gal-containing neoglycoprotein-based vaccine partially protects against murine cutaneous leishmaniasis caused by Leishmania major. PLoS Negl Trop Dis 11:e0006039
Szempruch, Anthony J; Sykes, Steven E; Kieft, Rudo et al. (2016) Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia. Cell 164:246-257
Peng, Xiuli; Jiang, Guozhong; Liu, Wei et al. (2016) Characterization of differential pore-forming activities of ESAT-6 proteins from Mycobacterium tuberculosis and Mycobacterium smegmatis. FEBS Lett 590:509-19
Dai, Liping; Peng, Xuan-Xian; Tan, Eng M et al. (2016) Tumor-associated antigen CAPER? and microvessel density in hepatocellular carcinoma. Oncotarget 7:16985-95
Schocker, Nathaniel S; Portillo, Susana; Brito, Carlos R N et al. (2016) Synthesis of Gal?(1,3)Gal?(1,4)GlcNAc?-, Gal?(1,4)GlcNAc?- and GlcNAc-containing neoglycoproteins and their immunological evaluation in the context of Chagas disease. Glycobiology 26:39-50
Zhang, Qi; Wang, Decheng; Jiang, Guozhong et al. (2016) EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5. Sci Rep 6:32618

Showing the most recent 10 out of 321 publications