The Molecular and Cellular Biology (MCB) Core Laboratory is one of fourteen multi-user core facilities in the College of Science, Engineering and Technology (CSET) at Jackson State University (JSU). The MCB Core Laboratory has been supported by the National Institutes of Health/Research Centers for Minority Institutions NIH/RCMI since the development of the Center for Environmental Health at JSU. This facility is equipped with shared equipment to conduct research in environmental health and biomedical science using molecular biology and recombinant DMA technologies. The facility is staffed with a faculty manager and a lab technician. During the current RCMI grant cycle, the MCB Core Laboratory has contributed to 52 peer-reviewed publications and 131 abstracts and presentations. MCB Core users have also received grants totaling $11,519,460 and submitted 5 pending grant proposals. Overall, the MCB Core Laboratory has had a tremendous impact on the development of biomedical research and the success of the RCMI Program at JSU. The facility currently supports the needs of RCMI investigators and their research personnel, as well as other faculty and students who are involved in biomedical research. The MCB Core Laboratory has recently been enhanced by the purchase of new equipment (phosphoimager and DMA sequencer) with funds from other sources. However, additional support from the NIH is critical for the continued operation of this biomedical research resource. Hence, the specific aims of the MCB Core Laboratory in this new application are: 1) To continue to provide a variety of services and technical support in molecular biology and DMA technology by offering equipment access, expert advice, demonstration of techniques, operation of equipment, participation in discussion and data interpretation, and hands-on-training in molecular biology and cell culture among RCMI investigators, pilot project recipients, and other faculty;2) To increase faculty training in recombinant DMA technology to strengthen faculty development and technology transfer;3) To provide a research environment and instrumentation for investigators to pursue biomedical research opportunities and enhance overall research productivity;and 4) To foster collaborative research relationships among RCMI investigators and other MCB core users at JSU and other research intensive institutions.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Research Centers in Minority Institutions Award (G12)
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Special Emphasis Panel (ZRR1-RI-1 (01))
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Jackson State University
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United States
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Johnson, Martha; Ates, Mehmet; Arslan, Zikri et al. (2017) Assessment of Crystal Morphology on Uptake, Particle Dissolution, and Toxicity of Nanoscale Titanium Dioxide on Artemia salina. J Nanotoxicol Nanomed 2:11-27
Portis, Bobby; Mirchi, Ali; Emami Khansari, Maryam et al. (2017) An Ideal C3-Symmetric Sulfate Complex: Molecular Recognition of Oxoanions by m-Nitrophenyl- and Pentafluorophenyl-Functionalized Hexaurea Receptors. ACS Omega 2:5840-5849
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Kaya, Hasan; Duysak, Müge; Akbulut, Mehmet et al. (2017) Effects of subchronic exposure to zinc nanoparticles on tissue accumulation, serum biochemistry, and histopathological changes in tilapia (Oreochromis niloticus). Environ Toxicol 32:1213-1225
Yilmaz, Vedat; Yilmaz, Hayriye; Arslan, Zikri et al. (2017) Novel Imprinted Polymer for the Preconcentration of Cadmium with Determination by Inductively Coupled Plasma Mass Spectrometry. Anal Lett 50:482-499
Ates, Mehmet; Demir, Veysel; Arslan, Zikri et al. (2016) Chronic exposure of tilapia (Oreochromis niloticus) to iron oxide nanoparticles: Effects of particle morphology on accumulation, elimination, hematology and immune responses. Aquat Toxicol 177:22-32
Akil, Luma; Ahmad, H Anwar (2016) Salmonella infections modelling in Mississippi using neural network and geographical information system (GIS). BMJ Open 6:e009255
Deng, Hua; McShan, Danielle; Zhang, Ying et al. (2016) Mechanistic Study of the Synergistic Antibacterial Activity of Combined Silver Nanoparticles and Common Antibiotics. Environ Sci Technol 50:8840-8
Howard, Carolyn B; McDowell, Roderick; Feleke, Kidus et al. (2016) Chemotherapeutic Vulnerability of Triple-negative Breast Cancer Cell-derived Tumors to Pretreatment with Vernonia amygdalina Aqueous Extracts. Anticancer Res 36:3933-43
Ates, Mehmet; Demir, Veysel; Arslan, Zikri et al. (2016) Toxicity of Engineered Nickel Oxide and Cobalt Oxide Nanoparticles to Artemia salina in seawater. Water Air Soil Pollut 227:

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