THIOAMIDE-BASED SENSOR FOR ANIONS OF ENVIRONMENTAL AND BIOMEDICAL
Selective binding of anions occurs in numerous physiological and enzymatic processes in life and is of paramount importance for many applications such as potential prototypes of new sensory devices, new extraction agents, and biological carriers. Surprisingly, synthetic receptors and sensors for anions are still very limited. The proposal will focus on developing new anion receptors, binders and sensors, which will have application in improving human health and the environment. The project is based on the hypothesis that the introduction of (C=S)NH, as a binding site to a synthetic receptor, enhances anion binding ability, and a fluorophore group if linked to the molecule displays a detectable optical change in presence of an anion. The long term goal of this project is to provide strategies for the design of highly selective sensor systems, and thus it will add a new dimension to the field of anion sensor chemistry.
In Specific Aim 1, a new series of thioamide-based receptors with different spacers and variable rigidity will be synthesized, which include (1) acyclic thioamide receptors with TREN, aromatic and crown ether units, (ii) macrocyclic thioamide receptors with variable spacers, and (iii) optical sensors containing pyrene and dansyl groups. Series (i) and (ii) will bind anions through (C=S)NH...X- interactions, while the signaling unit(s) in series (iii) will serve as anion sensing.
Specific Aim 2 is designed to investigate the binding properties of the synthesized molecules for anions in different solvents. The target anions are sulfate, phosphate, nitrate, perchlorate and halides, which are directly related to environment health and public health.
Specific Aim 3 will focus on isolating complexes of anions bound to our synthetic ligands, and determining the structure of those complexes by X-ray crystallography.
In Specific Aim 4, the cytotoxicity of thioamide-based ligands will be studied in both human liver carcinoma and human thyroid cancer cells using the MTT assay. Successful completion of this project will contribute greatly to the development of a framework for environmental and biomedical applications, and to the achievement the overall goals of RCMI at Jackson State University.
|Johnson, Martha; Ates, Mehmet; Arslan, Zikri et al. (2017) Assessment of Crystal Morphology on Uptake, Particle Dissolution, and Toxicity of Nanoscale Titanium Dioxide on Artemia salina. J Nanotoxicol Nanomed 2:11-27|
|Portis, Bobby; Mirchi, Ali; Emami Khansari, Maryam et al. (2017) An Ideal C3-Symmetric Sulfate Complex: Molecular Recognition of Oxoanions by m-Nitrophenyl- and Pentafluorophenyl-Functionalized Hexaurea Receptors. ACS Omega 2:5840-5849|
|Antwi-Boasiako, Afua A; Dunn, Derrick; Dasary, Samuel S R et al. (2017) Bioconjugated graphene oxide-based Raman probe for selective identification of SKBR3 breast cancer cells. J Raman Spectrosc 48:1056-1064|
|Kaya, Hasan; Duysak, Müge; Akbulut, Mehmet et al. (2017) Effects of subchronic exposure to zinc nanoparticles on tissue accumulation, serum biochemistry, and histopathological changes in tilapia (Oreochromis niloticus). Environ Toxicol 32:1213-1225|
|Yilmaz, Vedat; Yilmaz, Hayriye; Arslan, Zikri et al. (2017) Novel Imprinted Polymer for the Preconcentration of Cadmium with Determination by Inductively Coupled Plasma Mass Spectrometry. Anal Lett 50:482-499|
|Ates, Mehmet; Demir, Veysel; Arslan, Zikri et al. (2016) Chronic exposure of tilapia (Oreochromis niloticus) to iron oxide nanoparticles: Effects of particle morphology on accumulation, elimination, hematology and immune responses. Aquat Toxicol 177:22-32|
|Akil, Luma; Ahmad, H Anwar (2016) Salmonella infections modelling in Mississippi using neural network and geographical information system (GIS). BMJ Open 6:e009255|
|Deng, Hua; McShan, Danielle; Zhang, Ying et al. (2016) Mechanistic Study of the Synergistic Antibacterial Activity of Combined Silver Nanoparticles and Common Antibiotics. Environ Sci Technol 50:8840-8|
|Howard, Carolyn B; McDowell, Roderick; Feleke, Kidus et al. (2016) Chemotherapeutic Vulnerability of Triple-negative Breast Cancer Cell-derived Tumors to Pretreatment with Vernonia amygdalina Aqueous Extracts. Anticancer Res 36:3933-43|
|Ates, Mehmet; Demir, Veysel; Arslan, Zikri et al. (2016) Toxicity of Engineered Nickel Oxide and Cobalt Oxide Nanoparticles to Artemia salina in seawater. Water Air Soil Pollut 227:|
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