This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. A.
Specific Aims The Specific Aims have not changed. The Nanotechnology Core is aimed at incorporating all the advances in synthesis and characterization of nanostructured materials to the advance of biological and health sciences. In particular we would like to develop new methods of synthesis of nanoparticles in which non-toxic reducing agents are used and that can be applied to many areas. Our group has developed star shaped nanoparticle which can be used as contrast agents in cells using photo acoustic effects or plasmon resonances. (Fig. 1) Every peak acts as an antennae that enhances the electromagetic field around the particle. We are currently synthesizing particles using microwave radiation which avoids reducing salt and makes those particles bio compatible. One of the aims of the core is to optimize the fabrication of nanoparticles for use of UTSA researchers. The next objective of the Core is to make available all the new techniques of electron microscopy to biological and medical researchers. Our core has one of the top microscopes in the world and the objective is to apply techniques well establised in materials science to biology.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Centers in Minority Institutions Award (G12)
Project #
5G12RR013646-12
Application #
8357126
Study Section
Special Emphasis Panel (ZRR1-RI-B (01))
Project Start
2011-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
12
Fiscal Year
2011
Total Cost
$664,221
Indirect Cost
Name
University of Texas Health Science Center San Antonio
Department
Type
Other Domestic Higher Education
DUNS #
800189185
City
San Antonio
State
TX
Country
United States
Zip Code
78249
Ortega, Eduardo; Ponce, Arturo; Santiago, Ulises et al. (2017) Structural damage reduction in protected gold clusters by electron diffraction methods. Adv Struct Chem Imaging 2:12
Rodriguez, Roberto A; Chen, Liao Y; Plascencia-Villa, Germán et al. (2017) Elongation affinity, activation barrier, and stability of A?42 oligomers/fibrils in physiological saline. Biochem Biophys Res Commun 487:444-449
Mimun, L Christopher; Ajithkumar, G; Rightsell, Chris et al. (2017) Synthesis and characterization of Na(Gd0.5Lu0.5)F4: Nd3+,a core-shell free multifunctional contrast agent. J Alloys Compd 695:280-285
Srinivasan, Anand; Torres, Nelson S; Leung, Kai P et al. (2017) nBioChip, a Lab-on-a-Chip Platform of Mono- and Polymicrobial Biofilms for High-Throughput Downstream Applications. mSphere 2:
Raphael, Itay; Webb, Johanna; Gomez-Rivera, Francisco et al. (2017) Serum Neuroinflammatory Disease-Induced Central Nervous System Proteins Predict Clinical Onset of Experimental Autoimmune Encephalomyelitis. Front Immunol 8:812
Moritz, Robert J; LeBaron, Richard G; Phelix, Clyde F et al. (2016) Macrophage TGF-?1 and the Proapoptotic Extracellular Matrix Protein BIGH3 Induce Renal Cell Apoptosis in Prediabetic and Diabetic Conditions. Int J Clin Med 7:496-510
Mendoza-Cruz, Rubén; Bazán-Díaz, Lourdes; Velázquez-Salazar, J Jesús et al. (2016) Helical Growth of Ultrathin Gold-Copper Nanowires. Nano Lett 16:1568-73
Plascencia-Villa, Germán; Ponce, Arturo; Collingwood, Joanna F et al. (2016) High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer's disease. Sci Rep 6:24873
Rozinek, Sarah C; Thomas, Robert J; Brancaleon, Lorenzo (2016) Biophysical characterization of the interaction of human albumin with an anionic porphyrin. Biochem Biophys Rep 7:295-302
Pedraza, Francisco J; Avalos, Julio C; Yust, Brian G et al. (2016) Effect of surface coating of KYb2F7:Tm(3+) on optical properties and biomedical applications. Nanotechnology 27:385601

Showing the most recent 10 out of 174 publications