Surgical trauma occurs to blood vessels such as the human saphenous vein (HSV) when it is harvested from the lower extremity and transplanted into the arterial circulation as an arterial bypass graft. This project will determine the molecular mediators that lead to decreased function of HSV and blood vessels after surgical injury. Since ?the response to injury? has been implicated in modulating vein graft failure, a better understanding of the molecular mechanisms of surgical trauma would decrease myocardial infarction, re-do operations and limb loss associated with vein graft failure. This work will also provide new insights in pathologic surgical injury with potential extensions to other applications such as vascular injury during angioplasty, transplantation, and trauma.

Public Health Relevance

Surgery causes trauma to tissues. For example, harvest of human saphenous vein for use as a vascular conduit leads to injury to the vessel. This proposal will use a model of surgical trauma to blood vessels to examine the molecular mediators of surgical trauma and the mechanisms by which trauma leads to impaired function. This will lead to new insights in our understanding of surgical injury to blood vessels, the vascular response to that injury, and new modalities to prevent and treat surgical vascular injury.

Agency
National Institute of Health (NIH)
Institute
Veterans Affairs (VA)
Type
Non-HHS Research Projects (I01)
Project #
5I01BX003882-02
Application #
9678196
Study Section
Surgery (SURG)
Project Start
2017-10-01
Project End
2021-09-30
Budget Start
2018-10-01
Budget End
2019-09-30
Support Year
2
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Veterans Health Administration
Department
Type
DUNS #
156385783
City
Nashville
State
TN
Country
United States
Zip Code
37212