Excessive alcohol use (EAU) is becoming recognized as an emerging health-related problem especially among veterans returning from combats. There is a need for increased vigilance and action to identify and counsel these at-risk veterans. Unfortunately, we lack the reliable diagnostic tests to detect the dangerous levels of drinking. Such tests would be indispensable for screening and care for veterans with excessive alcohol use. We hypothesize that several novel serum and urine markers based on the effect of alcohol on immune cells can be used as the predictive biomarkers for EAU. To test this hypothesis, we plan to pursue the following specific aims.
SPECIFIC AIM # 1. To determine the effect of EAU on organ systems using system biology and by detecting, identifying, and comparing the relative quantity of these novel targets and evaluate these as potential biomarkers and SPECIFIC AIM # 2. To determine the predictive capacity of these biomarkers for alcohol-related health consequences. If successful, the results from this project will revolutionize the screening methods for veterans with excessive alcohol use.

Public Health Relevance

Excessive alcohol use (EAU) is becoming recognized as an emerging health-related problem especially among veterans returning from combats. Based on the results from our previous VA merit review funding, we found that several novel serum and urine markers based on the effect of alcohol on specific cell types can be used as the predictive biomarkers for EAU. We propose to systematically study these markers as the predictive of EAU and the quantity of recent alcohol consumption. Further, we will determine the predictive capacity of these markers for alcohol-related health consequences.

Agency
National Institute of Health (NIH)
Institute
Veterans Affairs (VA)
Type
Non-HHS Research Projects (I01)
Project #
5I01CX000361-06
Application #
9591294
Study Section
Neurobiology A (NURA)
Project Start
2011-10-01
Project End
2021-09-30
Budget Start
2018-10-01
Budget End
2019-09-30
Support Year
6
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Rlr VA Medical Center
Department
Type
DUNS #
608434697
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
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