In the course of completing our study, "Stroke Prevention in Atrial Fibrillation: Impact of Mental Illness" (IIR 04- 248), we learned that half of Veterans receiving warfarin in VA actually received INR testing in Medicare (MC) during Fiscal Year 2004 (FY04), suggestion that some anticoagulation care was occurring outside VA and that Veterans were engaging in DU of VA and Medicare anticoagulation services. Moreover, patients with INR testing in VA+MC had lower unadjusted frequencies of anticoagulation process measures, suggesting that dual care was not supplementary but may be causing harm. Failure to coordinate VA AF patients'care could increase risk for strokes, bleeds and death. Our study investigates whether patients treated with warfarin who receive care in both VA and Medicare have poorer outcomes. We also examine whether dual users are less likely to receive regular INR tests. If dual use is associated with adverse outcomes, important implications could follow: 1. Patients might consider using a single institution of all their AF care. 2. Clinicians might heighten their vigilance about monitoring anticoagulation care in dual users. 3. Health care systems might consider implementing systems that optimize coordination of services between VA and the private sector. We propose the following objectives in studying Veterans with AF receiving warfarin in VA: 1. To characterize patterns of Dual Use (VA+MC) 2. To determine the effect of DU on processes of anticoagulation care 3. To determine the effect of DU on outcomes of AF care (stroke, hemorrhage, death) We will apply approaches developed by our team for IIR 04-248 to create a cohort of Veterans VA users with prevalent AF on warfarin therapy during the observation period. A major strength of our plan is that we can apply methods and protocols that we developed for IIR 04-248 that are specialized to AF research using VA and CMS data (e.g., for merging databases and for identification of AF, outcomes of AF care);while assembly of these multiple complex databases using updated data sources will still be labor-intensive, our prior experience will improve our efficiency, making it possible for us to propose a markedly shortened (2 -year) project timeline. In this way we will leverage VA resources by building on prior work to answer critical questions about ramifications of today's heterogeneous U.S. health care delivery system. Data will be drawn from existing sources: VA's National Patient Care Database, VA's Decision Support System, VA's Vital Status file, and Medicare data. Varying definitions of DU will be examined, with a focus on DU based on receipt of INR monitoring in VA and Medicare. Strokes and bleeds will be identified from ICD9 codes using existing algorithms. Death will be identified from VA's Vital Status file. INR monitoring will be identified from lab and CPT codes, and Time in Therapeutic Range from INR values.

Public Health Relevance

Prevention of stroke is a major Veterans Health Administration (VA) priority, given the high morbidity and cost of stroke. Atrial fibrillation and atrial flutter (AF, collectively) are abnormal heart rhythms that affect 5-8.3% of all Veterans and cause 15% of the 700,000 strokes per year in the United States. Anticoagulation with warfarin can decrease stroke in patients with AF. However, warfarin has a narrow therapeutic window, necessitating careful monitoring of anticoagulation blood levels (INR). Concerns that VA AF patients with dual use (DU) of VA and Medicare services, who may receive disjointed care, could be at risk for dangerous fluctuations in INR level. This could potentially lead to strokes, hemorrhage, and death. This possibility requires immediate attention due to major patient safety implications that extend to other systems of care and health conditions in Veterans and to non-VA patients.

Agency
National Institute of Health (NIH)
Institute
Veterans Affairs (VA)
Type
Non-HHS Research Projects (I01)
Project #
1I01HX000116-01A2
Application #
8198390
Study Section
HSR-1 Medical Care and Clinical Management (HSR1)
Project Start
2011-09-01
Project End
2014-02-28
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
1
Fiscal Year
2013
Total Cost
Indirect Cost
Name
Veterans Admin Palo Alto Health Care Sys
Department
Type
DUNS #
046017455
City
Palo Alto
State
CA
Country
United States
Zip Code
94304