Impairment in hand motor function is a major deficit in veterans with cervical spinal cord injury (SCI). While rehabilitative interventions have shown success in improving aspects of hand motor function their overall effects remain limited. The goals of this proposal are to examine the physiology of CNS pathways contributing to the control of hand movements after cervical SCI, and to promote the recovery of hand movements by using non-invasive brain stimulation and motor training. We focus on two basic aspects involved in hand motor function: a precision grip and wrist flexion and extension. These are necessary skills for most of our daily-life activities; therefore, our results may directly impact the quality of life for veterans and their caregivers by enhancing their independence and level of care. We will investigate the contribution of the motor cortex and spinal motoneurons to the control of muscles involved in precision grip and wrist movements after cervical SCI (Aim 1). Transcranial magnetic stimulation (TMS) will be used to examine transmission in corticospinal and intracortical pathways targeting finger and wrist muscles, whereas peripheral nerve stimulation will be used to assess the excitability of finger and wrist motoneurons. These studies will identify the effects of SCI on CNS pathways controlling hand movements. Then, we propose to enhance the recovery of hand motor function by using novel protocols of high frequency non-invasive repetitive TMS (rTMS) and motor training (Aim 2). First, rTMS will be used during precision grip and wrist movements in a task- dependent manner to induce cortical plasticity and enhance voluntary output of hand muscles. Second, rTMS will be applied in a task-dependent manner during a visuo-motor training task that involves precision grip and wrist movements. These unique approaches aim at promoting neuroplasticity during functionally relevant hand movements, which has not been done before. The proposed studies tightly couple basic scientific human research and translational neuroscience. The novel approaches of non-invasive brain stimulation may open new directions for restoring hand motor function after SCI. The absence of well-accepted treatments for hand motor impairments for veterans with cervical SCI and the limited behavioral gains of present interventions underline the importance of these investigations.

Public Health Relevance

Hand motor function is largely disrupted in Veterans with cervical SCI. This has tremendous impact on daily-life activities. This proposal will examine physiological changes in pathways controlling hand motor function after cervical SCI and novel methods to enhance the recovery of hand motor function by combining non-invasive repetitive brain stimulation with motor training. Impairment in hand function is a major problem after stroke, amyotrophic lateral sclerosis, multiple sclerosis, and other motor disorders, therefore, our work may also be relevant for individuals with other lesions of the CNS.

Agency
National Institute of Health (NIH)
Institute
Veterans Affairs (VA)
Type
Non-HHS Research Projects (I01)
Project #
5I01RX000815-06
Application #
9398907
Study Section
Spinal Cord Injury (RRDA)
Project Start
2013-10-01
Project End
2018-12-31
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
6
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Miami VA Health Care System
Department
Type
DUNS #
079275714
City
Miami
State
FL
Country
United States
Zip Code
33125
Macklin, Richard A; Bae, Jihye; Orell, Melanie et al. (2017) Time-Dependent Discrepancies between Assessments of Sensory Function after Incomplete Cervical Spinal Cord Injury. J Neurotrauma 34:1778-1786
Tazoe, Toshiki; Perez, Monica A (2017) Cortical and reticular contributions to human precision and power grip. J Physiol 595:2715-2730
Lei, Yuming; Perez, Monica A (2017) Cortical contributions to sensory gating in the ipsilateral somatosensory cortex during voluntary activity. J Physiol 595:6203-6217
Long, Jinyi; Federico, Paolo; Perez, Monica A (2017) A novel cortical target to enhance hand motor output in humans with spinal cord injury. Brain 140:1619-1632
Federico, Paolo; Perez, Monica A (2017) Altered corticospinal function during movement preparation in humans with spinal cord injury. J Physiol 595:233-245
Cirillo, John; Calabro, Finnegan J; Perez, Monica A (2016) Impaired Organization of Paired-Pulse TMS-Induced I-Waves After Human Spinal Cord Injury. Cereb Cortex 26:2167-77
Long, Jinyi; Tazoe, Toshiki; Soteropoulos, Demetris S et al. (2016) Interhemispheric connectivity during bimanual isometric force generation. J Neurophysiol 115:1196-207
Macklin, R A; Brooke, V J; Calabro, F J et al. (2016) Discrepancies between clinical assessments of sensory function and electrical perceptual thresholds after incomplete chronic cervical spinal cord injury. Spinal Cord 54:16-23
Calabro, Finnegan J; Perez, Monica A (2016) Bilateral reach-to-grasp movement asymmetries after human spinal cord injury. J Neurophysiol 115:157-67
Perez, Monica A; Rothwell, John C (2015) Distinct influence of hand posture on cortical activity during human grasping. J Neurosci 35:4882-9

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