Although emotion-based dispositions toward rash action have shown to be uniquely predictive of increased alcohol consumption and increased alcohol-related problems, research has yet to determine (1) the neurobiological and cognitive mechanisms by which emotion-based impulsivity predicts increased alcohol consumption and problems and (2) that these behaviors actually occur in response to emotional manipulation, as predicted by the traits. Positive urgency (PUR) and negative urgency (NUR) are personality traits that relate to an individual's tendency to act rashly in response to extreme positive and negative mood states, respectively;these traits predict increased alcohol consumption and problems associated with alcohol use. For example, individuals high in PUR/NUR are at a greater risk to drink (or participate in some other risk-taking behavior) in response to a positive event (such as getting a raise at work or an important sports win) or a negative event (such as a romantic breakup, a failed exam, or a fight with family). The overall objective of this research project is to examine the brain system activation and lab-based alcohol use of individuals high in urgency and examine the effect of these factors on risk for increased alcohol consumption and alcohol-related problems, as part of the examination of my model of risk. The central hypotheses of this project are: (1) Individuals high in NUR will be more responsive to reward cues, as manifested by increased medial prefrontal activation from alcoholic drink aromas (see Kareken et al., 2010) after a negative mood induction than pre-mood induction;(2) Individuals high in PUR will show increased medial prefrontal activation in response to alcohol aromas after a positive mood induction than pre-mood induction, (3) The relationship between mood and increased prefrontal activation will be mediated by alcohol expectancies activation, and (4) induced mood states will lead to increased self-administration of alcohol as moderated by the urgency traits and mediated by alcohol expectancies. After completing these projects, there will be a better understanding of specific neurobiological underpinnings that are involved in urgent action and of specific expectancy activation that mediate the relationship between urgency and risky alcohol consumption. I expect that this understanding will allow for greater specificity in designing treatments by helping to understand which individuals are most cue-responsive, as well as paving the way toward an R01 application to determine if treatments can assist such individuals in managing cognitive strategies.

Public Health Relevance

The use of alcohol during extreme emotional states has been shown to predict increased levels of alcohol consumption and alcohol-related problems in young adult populations. This project will contribute to our understanding of the risk processes for alcohol use involvement among young adults, which will have value for: (a) understanding which individuals are at greatest risk for alcohol abuse and (b) developing effective prevention programs.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
1K01AA020102-01A1
Application #
8189701
Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Matochik, John A
Project Start
2011-09-01
Project End
2016-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
1
Fiscal Year
2011
Total Cost
$157,212
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Hao, Guangshu; Wang, Dan; Sun, Yanni et al. (2017) Association of blood glucose and lipid levels with complete blood count indices to establish a regression model. Biomed Rep 6:339-345
Shi, Ming; Liu, Zhenwen; Wang, Ying et al. (2017) A Pilot Study of Mesenchymal Stem Cell Therapy for Acute Liver Allograft Rejection. Stem Cells Transl Med 6:2053-2061
Zhang, Xiaoqian; Lu, Juan; He, Bin et al. (2017) A tryptophan derivative, ITE, enhances liver cell metabolic functions in vitro. Int J Mol Med 39:101-112
Huang, Guoliang; Huang, Qin; Xie, Lan et al. (2017) A rapid, low-cost, and microfluidic chip-based system for parallel identification of multiple pathogens related to clinical pneumonia. Sci Rep 7:6441
Zheng, Wen; Yu, Cheuk-Man; Liu, Jing et al. (2017) Patients with ST-segment elevation of myocardial infarction miss out on early reperfusion: when to undergo delayed revascularization. J Geriatr Cardiol 14:524-531
Yan, Yan; Wang, Xiao; Fan, Jing-Yao et al. (2017) Impact of triple antithrombotic therapy in patients with acute coronary syndrome undergoing percutaneous coronary intervention in real-world practice. J Geriatr Cardiol 14:679-687
Yu, Jiong; Pan, Qiaoling; Yang, Jinfeng et al. (2017) Correlations of Complete Blood Count with Alanine and Aspartate Transaminase in Chinese Subjects and Prediction Based on Back-Propagation Artificial Neural Network (BP-ANN). Med Sci Monit 23:3001-3009
VanderVeen, J Davis; Plawecki, Martin H; Millward, James B et al. (2016) Negative urgency, mood induction, and alcohol seeking behaviors. Drug Alcohol Depend 165:151-8
Wang, Yini; Yu, Xiaopeng; Chen, Ermei et al. (2016) Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases. Stem Cell Res Ther 7:71
Hu, Chenxia; Fan, Linxiao; Cen, Panpan et al. (2016) Energy Metabolism Plays a Critical Role in Stem Cell Maintenance and Differentiation. Int J Mol Sci 17:253

Showing the most recent 10 out of 32 publications