The goals for this K01 proposal principally derive from a desire to better articulate and understand the processes and mechanisms associated with the development of alcohol use, abuse, and dependence. Integrative Data Analysis (IDA) has been identified as a useful framework for analyzing pooled data from extant longitudinal studies, and proffers a number of advantages over the discrete analysis of independent datasets. Specifically, IDA has the potential to (i) broaden the psychometric assessment of target constructs, (ii) extend the period of development under investigation, and (iii) provide direct tests of replication, all while increasing (iv) frequencies of low base-rate, high-risk behavior/trajectories, (v) representation of typically underrepresented subgroups, and (vi) statistical power. Fully capitalizing on this potential is, however, predicated on an ability to develop commensurate measures across independent studies, units of time, and psychometric instruments. With abundant evidence prospectively linking early externalizing behavior with drinking problems in adulthood, the focus of this project is on the phenotypic refinement of general externalizing problems within and across the following three studies: the Child Development Project, the Fast Track Project, and the Mobile Youth Survey. In doing so, various statistical methods for addressing measurement non-invariance will be applied and compared, including longitudinal extensions of item-response theory and, if possible, moderated non-linear factor analysis. The resultant reductions in measurement error are expected to yield more reliable and valid characterizations (both quantitative and qualitative) of the development of externalizing behavior, and to improve on our ability to identify critical early environmental and genetic antecedents of high-risk trajectories, as well as their alcohol-related sequelae in adulthood. As such, in the latter stages of the award it will be possible to directly assess the extent to which IDA procedures replicate, extend, and/or improve upon traditional single-study longitudinal analyses, and whether potential sources of between-study heterogeneity further inform on findings derived from data for which measurement non- invariance has been addressed across pooled samples.

Public Health Relevance

This K01 award will provide the applicant with the training and resources necessary to establish a program of research that will more precisely articulate the externalizing pathways and associated mechanisms involved in the development of alcohol use, problems, and disorders. The proposed project's goal of refining the phenotypic measurement of externalizing behaviors from which trajectories of risk can be derived will help identify the most plausible and generalizable conditions under which genetic and early environmental factors might independently and/or interactively influence alcohol-related behaviors in adulthood.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01AA020333-02
Application #
8248806
Study Section
Health Services Research Review Subcommittee (AA)
Program Officer
Zha, Wenxing
Project Start
2011-04-01
Project End
2016-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
2
Fiscal Year
2012
Total Cost
$174,279
Indirect Cost
$12,910
Name
Virginia Commonwealth University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
Aliev, Fazil; Latendresse, Shawn J; Bacanu, Silviu-Alin et al. (2014) Testing for measured gene-environment interaction: problems with the use of cross-product terms and a regression model reparameterization solution. Behav Genet 44:165-81
Swann, Gregory; Byck, Gayle R; Dick, Danielle M et al. (2014) Effect of OPRM1 and stressful life events on symptoms of major depression in African American adolescents. J Affect Disord 162:12-9
Dick, Danielle M; Cho, Seung Bin; Latendresse, Shawn J et al. (2014) Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood. Addict Biol 19:1055-64
Edwards, Alexis C; Latendresse, Shawn J; Heron, Jon et al. (2014) Childhood internalizing symptoms are negatively associated with early adolescent alcohol use. Alcohol Clin Exp Res 38:1680-8
Latendresse, Shawn J; Bates, John E; Goodnight, Jackson A et al. (2011) Differential susceptibility to adolescent externalizing trajectories: examining the interplay between CHRM2 and peer group antisocial behavior. Child Dev 82:1797-814