Donna H. Korzick, Ph.D. is a physiologist currently supported by a T32 Training National Research Service Award from NIH. Dr. Korzick has demonstrated significant commitment to research activities in the area of adrenergic regulation of cardiac contractile function as it pertains to chronic endurance exercise and cardiac pathophysiology. The KO1 Mentored Research Scientist Development Award would enable her to build upon past research experiences and compliment her current research skills with the intent of establishing an independent reseach career in the field of cardiovascular aging. Career Development/Training Plan: The training activities outlined for the duration of this award include a particular emphasis on acquisition of a significant number of molecular and biochemical techniques in the area of receptor-second messenger coupling. Attendance of seminars in pharmacology, physiology and veterinary biomedical sciences will foster interactions with individuals with diverse backgrounds and interests. A unique aspect of this plan includes the team of consulting mentors associated with this application. A team of renowned investigators are committed to Dr. Korzick's mentoring and training with regard to their respective disciplines and direct interactions will occur as needed. Research Plan: An important compensatory role for the alpha1-adrenergic receptor (alpha1-AR) system in regulating cardiac contractile function in a variety of cardiac pathologies has recently been proposed. Observations from senescent myocardium, however, suggest the inotropic responsiveness of the heart to alpha1-AR stimulation is blunted rather than enhanced, further diminishing the functional reserve capacity of the aging rat ventricle. Preliminary studies suggest that this response may be mediated by diminished effectiveness of the PKC-dependent arm of the alpha1-AR signal transduction pathway. The contribution of other alpha1-AR signaling cascade components are unknown. This proposal will systematically evaluate cellular changes in alpha1-AR signal transduction responsible for alpha1-AR contractile dysfunction in rat heart. Studies will also address the role of chronic exercise in attenuating age-related aberrations in alpha1-AR mediated contractile function and underlying mechanisms. Environment: The environment surrounding Dr. Korzick at the University of Missouri is one marked by a commitment to research and academic scholarship with major strengths in cardiovascular sciences.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01AG000875-06
Application #
6605742
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Kohanski, Ronald A
Project Start
1999-07-01
Project End
2005-06-30
Budget Start
2003-07-01
Budget End
2005-06-30
Support Year
6
Fiscal Year
2003
Total Cost
$123,093
Indirect Cost
Name
Pennsylvania State University
Department
Miscellaneous
Type
Schools of Allied Health Profes
DUNS #
003403953
City
University Park
State
PA
Country
United States
Zip Code
16802
Boluyt, Marvin O; Cirrincione, Georgina M; Loyd, Amy M et al. (2007) Effects of gradual coronary artery occlusion and exercise training on gene expression in swine heart. Mol Cell Biochem 294:87-96
Kostyak, John C; Hunter, J Craig; Korzick, Donna H (2006) Acute PKCdelta inhibition limits ischaemia-reperfusion injury in the aged rat heart: role of GSK-3beta. Cardiovasc Res 70:325-34
Korzick, Donna H; Muller-Delp, Judy M; Dougherty, Patrick et al. (2005) Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase C. Cardiovasc Res 66:384-92
Hunter, J Craig; Korzick, Donna H (2005) Age- and sex-dependent alterations in protein kinase C (PKC) and extracellular regulated kinase 1/2 (ERK1/2) in rat myocardium. Mech Ageing Dev 126:535-50
Maddali, K K; Korzick, D H; Turk, J R et al. (2005) Isoform-specific modulation of coronary artery PKC by glucocorticoids. Vascul Pharmacol 42:153-62
Korzick, Donna H; Rishel, Megan E; Bowles, Douglas K (2005) Exercise and hypercholesterolemia produce disparate shifts in coronary PKC expression. Med Sci Sports Exerc 37:381-8
Hunter, J Craig; Korzick, Donna H (2005) Protein kinase C distribution and translocation in rat myocardium: Methodological considerations. J Pharmacol Toxicol Methods 51:129-38
Korzick, D H; Laughlin, M H; Bowles, D K (2004) Alterations in PKC signaling underlie enhanced myogenic tone in exercise-trained porcine coronary resistance arteries. J Appl Physiol 96:1425-32
Kim, Min-ho; Harris, Norman R; Korzick, Donna H et al. (2004) Control of the arteriolar myogenic response by transvascular fluid filtration. Microvasc Res 68:30-7
Korzick, Donna H; Hunter, James C; McDowell, Mark K et al. (2004) Chronic exercise improves myocardial inotropic reserve capacity through alpha1-adrenergic and protein kinase C-dependent effects in Senescent rats. J Gerontol A Biol Sci Med Sci 59:1089-98

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