This amended proposal is for a K01 Mentored Research Scientist Development Award. The applicant is an epidemiologist and developing investigator at the Yale School of Medicine. Her goal is to become an expert and leader in the epidemiology of aging at the interface of psychosocial epidemiology and functional status. Her approach to achieving this goal is to learn advanced statistical methodology to elucidate the relationship between depression and disability over time in light of the emerging paradigm of disability as dynamic and highly complex. The proposed training and research plans are designed to complement and reinforce one another. The specific training objectives are to (1) acquire expertise in the epidemiology of disability and depression and obtain new skills in primary data collection;(2) develop expertise in the analysis of complex longitudinal data;(3) develop and refine a set of "survival" skills that are critical for a successful career as an independent investigator (e.g., grant writing);and (4) enhance her knowledge base regarding innovative research in aging. A secondary goal is to gain "hands-on" knowledge of the development and implementation of clinical trials research. The proposed research is designed to rigorously evaluate the reciprocal nature of the relationship between depression and disability, operationalized as disability burden and clinically-meaningful subtypes. Additionally, the applicant proposes to systematically determining the mechanisms that underlie the reciprocal relationship between depression and disability, and to evaluate if this relationship differs according to gender. The research will be conducted using data from the Yale PEP (Precipitating Events Project) Study, an ongoing NIA-funded, longitudinal study of 754 initially non-disabled community-living older persons. The conceptual and methodological challenges of using these data to test hypotheses directed at determining if a feedback loop exists between depression and disability over time will reinforce the applicant's formal training. Research that improves our understanding of how depression influences the complex trajectory of disability is highly significant to the field of aging;it will highlight a factor that, if adequately identified and managed, could help to prevent the development and progression of disability. Alternately, improving our understanding of this relationship may help to identify opportunities to prevent the development and progression of depression.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Scientist Development Award - Research & Training (K01)
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National Institute on Aging Initial Review Group (NIA)
Program Officer
Patmios, Georgeanne E
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University of Connecticut
Other Health Professions
Schools of Medicine
United States
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Barry, Lisa C; Thorpe Jr, Roland J; Penninx, Brenda W J H et al. (2014) Race-related differences in depression onset and recovery in older persons over time: the health, aging, and body composition study. Am J Geriatr Psychiatry 22:682-91
Barry, Lisa C; Soulos, Pamela R; Murphy, Terrence E et al. (2013) Association between indicators of disability burden and subsequent depression among older persons. J Gerontol A Biol Sci Med Sci 68:286-92
Barry, Lisa C; Abou, Janet J; Simen, Arthur A et al. (2012) Under-treatment of depression in older persons. J Affect Disord 136:789-96
Matthews, Margaret M; Hsu, Fang-Chi; Walkup, Michael P et al. (2011) Depressive symptoms and physical performance in the lifestyle interventions and independence for elders pilot study. J Am Geriatr Soc 59:495-500
Barry, Lisa C; Murphy, Terrence E; Gill, Thomas M (2011) Depressive symptoms and functional transitions over time in older persons. Am J Geriatr Psychiatry 19:783-91
Lichtman, Judith H; Naert, Lisa; Allen, Norrina B et al. (2011) Use of antithrombotic medications among elderly ischemic stroke patients. Circ Cardiovasc Qual Outcomes 4:30-8
Barry, Lisa C; Murphy, Terrence E; Gill, Thomas M (2011) Depression and functional recovery after a disabling hospitalization in older persons. J Am Geriatr Soc 59:1320-5
Martinez, Diane J; Kasl, Stanislav V; Gill, Thomas M et al. (2010) Longitudinal association between self-rated health and timed gait among older persons. J Gerontol B Psychol Sci Soc Sci 65:715-9
Barry, Lisa C; Allore, Heather G; Bruce, Martha L et al. (2009) Longitudinal association between depressive symptoms and disability burden among older persons. J Gerontol A Biol Sci Med Sci 64:1325-32
Gill, Thomas M; Murphy, Terrence E; Barry, Lisa C et al. (2009) Risk factors for disability subtypes in older persons. J Am Geriatr Soc 57:1850-5