The aim of this proposal is to provide the PI the opportunity to pursue theoretical and methodological development in a new field of research on explanatory models of sex differences in mortality in human populations across the life course. This will be accomplished by permitting me to seek training in the biological sciences to create an integrated social and biodemographic approach. The goal is to extend my previous training within the population level of analysis to interdisciplinary research on the interconnections between social forces and the biological processes of disease across levels of organization. The training focuses on population studies of biological mechanisms of inflammation and infections, fat and glucose metabolism aka metabolic syndrome, sex differences in these biological functions, their genetic origins and relationships to sex hormonal changes over the course of human development and aging, evolution of sex differences and basics of heritable genetic diseases.

Public Health Relevance

The aim of this proposal is to provide the PI the opportunity to pursue theoretical and methodological development in a new field of research on explanatory models of sex differences in mortality in human populations across the life course. This will be accomplished by permitting me to seek training in the biological sciences to create an integrated social and biodemographic approach. The goal is to extend my previous training within the population level of analysis to interdisciplinary research on the interconnections between social forces and the biological processes of disease across levels of organization.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01AG036745-04
Application #
8513862
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Patmios, Georgeanne E
Project Start
2010-08-01
Project End
2015-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
4
Fiscal Year
2013
Total Cost
$120,339
Indirect Cost
$8,914
Name
University of North Carolina Chapel Hill
Department
Social Sciences
Type
Schools of Arts and Sciences
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Yang, Yang Claire; Boen, Courtney; Mullan Harris, Kathleen (2015) Social relationships and hypertension in late life: evidence from a nationally representative longitudinal study of older adults. J Aging Health 27:403-31
Yang, Yang Claire; Li, Ting; Frenk, Steven M (2014) Social network ties and inflammation in U.S. adults with cancer. Biodemography Soc Biol 60:21-37
Yang, Yang Claire; Schorpp, Kristen; Harris, Kathleen Mullan (2014) Social support, social strain and inflammation: evidence from a national longitudinal study of U.S. adults. Soc Sci Med 107:124-35
Yang, Yang Claire; Land, Kenneth C (2013) Misunderstandings, mischaracterizations, and the problematic choice of a specific instance in which the IE should never be applied. Demography 50:1969-71; discussion 1985-8
Short, Susan E; Yang, Yang Claire; Jenkins, Tania M (2013) Sex, gender, genetics, and health. Am J Public Health 103 Suppl 1:S93-101
Yang, Yang Claire; McClintock, Martha K; Kozloski, Michael et al. (2013) Social isolation and adult mortality: the role of chronic inflammation and sex differences. J Health Soc Behav 54:183-203
Robinson, W R; Keyes, K M; Utz, R L et al. (2013) Birth cohort effects among US-born adults born in the 1980s: foreshadowing future trends in US obesity prevalence. Int J Obes (Lond) 37:448-54
Li, Ting; Yang, Yang Claire; Anderson, James J (2013) Mortality increase in late-middle and early-old age: heterogeneity in death processes as a new explanation. Demography 50:1563-91
Yang, Yang; Kozloski, Michael (2012) Change of sex gaps in total and cause-specific mortality over the life span in the United States. Ann Epidemiol 22:94-103
Yang, Yang; Kozloski, Michael (2011) Sex differences in age trajectories of physiological dysregulation: inflammation, metabolic syndrome, and allostatic load. J Gerontol A Biol Sci Med Sci 66:493-500