This is an application for a Mentored Research Scientist Development Award (K01). The goal of the proposed project is to provide the applicant with the advanced skills needed to establish an independent research program in cognitive aging using neuroimaging approach to understanding neural basis underlying age-related cognitive changes. The Applicant proposes a comprehensive training plan which combines didactic instruction with established researchers;formal coursework;participation in ongoing seminars in Columbia University, one-to-one directed readings with mentors, and finally conduction of a prospective pilot study from beginning to end. The goal of this study will be to explore the difference in the event-related fMRI activation of young and old healthy participants groups during a delayed item recognition task. Two new approaches are proposed in this project to address;a) poor localization of fMRI data analysis and b) lack of effective measure of subjective task difficulty. This project will take advantage of three of the on-going studies data n the Cognitive Neuroscience Division for the development and evaluation of the proposed methodologies. In addition, a new pilot study will be collected with a revised delayed letter recognition task which is specifically designed for the goal of this project. The proposed project aims will therefore elucidate the interrelationships between multiple measures of neurobiological changes associated with aging and will serve as a bridge for the applicant to establish an independent investigator career in conducting neuroimaging studies in aging populations.

Public Health Relevance

Two major longstanding problems in functional imaging studies comparing event-related fMRI activation in young and old groups is a) the large age-related changes in brain morphology makes it difficult to co-register brains, and b) the lack of control for subjective task difficulty on observed differences in event-related activation between young and older individuals. The current research proposes two new methodologies to address above issues and utilized them in examination of the age difference in the old and young brains activation while performing a memory task.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Scientist Development Award - Research & Training (K01)
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Application #
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Wagster, Molly V
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Columbia University
Schools of Medicine
New York
United States
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Gazes, Yunglin; Li, Peipei; Sun, Emily et al. (2018) Age specificity in fornix-to-hippocampus association. Brain Imaging Behav :
Eich, Teal S; Gonçalves, Beatriz M M; Nee, Derek E et al. (2018) Inhibitory Selection Mechanisms in Clinically Healthy Older and Younger Adults. J Gerontol B Psychol Sci Soc Sci 73:612-621
Razlighi, Qolamreza R (2018) Task-Evoked Negative BOLD Response in the Default Mode Network Does Not Alter Its Functional Connectivity. Front Comput Neurosci 12:67
Eich, Teal S; Razlighi, Qolamreza R; Stern, Yaakov (2017) Perceptual and memory inhibition deficits in clinically healthy older adults are associated with region-specific, doubly dissociable patterns of cortical thinning. Behav Neurosci 131:220-5
Grinband, Jack; Steffener, Jason; Razlighi, Qolamreza R et al. (2017) BOLD neurovascular coupling does not change significantly with normal aging. Hum Brain Mapp :
Razlighi, Qolamreza R; Oh, Hwamee; Habeck, Christian et al. (2017) Dynamic Patterns of Brain Structure-Behavior Correlation Across the Lifespan. Cereb Cortex 27:3586-3599
Parker, David; Liu, Xueqing; Razlighi, Qolamreza R (2017) Optimal slice timing correction and its interaction with fMRI parameters and artifacts. Med Image Anal 35:434-445
Razlighi, Qolamreza R; Habeck, Christian; Barulli, Daniel et al. (2017) Cognitive neuroscience neuroimaging repository for the adult lifespan. Neuroimage 144:294-298
Liu, Xueqing; Gerraty, Raphael T; Grinband, Jack et al. (2017) Brain atrophy can introduce age-related differences in BOLD response. Hum Brain Mapp :
Habeck, C; Razlighi, Q; Gazes, Y et al. (2017) Cognitive Reserve and Brain Maintenance: Orthogonal Concepts in Theory and Practice. Cereb Cortex 27:3962-3969

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