Human monkeypox(MPX) is a smallpox-likedisease primarily reported in the rainforestsof CentralAfrica. Until recently, MPX was considered a rare zoonoticinfection in humans;howeverthe dramatic increase in ?eports of human MPX over the last decade in the DemocraticRepublic of Congo(DRC) and recent outbreaks in the United States, Republic of Congo,and Sudan underscore the importance of understanding tie capacity and geographic rangefor disease emergence.To study the risk factors driving MPXgeographic distribution, prevalence, and risk of future emergence necessitates an interdisciplinary approach. The candidate proposes to undertake three primary career development activities: 1)training in remote sensing and spatial statistics;2) training to understandthe fundamental aspects of specimen processing and analysis, including virus growth, PCR, sequencing of MPX virus specimens;and 3) training in advanced pidemiologic methodsto integrate ecologicand laboratorydata with epidemiologic and clinical data/These training objectives are linked to the following research objectives: 1) to determine if prevalence and geographic distribution of human MPX has increased over time;2) to identify behavioral, demographic and environmental risk factors for human MPX infection;and 3) to understandthe role played by differential transmission and evolution of MPX.The researchcomponent will supplement and leverage a unique collection of biological specimens, existing research infrastructure in DRC, and access to remotely sensed data sets. The proposed research represents the first study in two decades to assessthe prevalence of MPX in an endemic region and to establish if the epidemiology of the virus has changed over time. Together, the career development and research activitiesproposedin this application will advance understanding of the variables that drive emergence of human MPX and support the development of the candidate as a productive independent investigator with the capacity to study fundamental ecologic, epidemiologic and biologic drivers of viral emergence.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01AI074810-05
Application #
8259747
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Challberg, Mark D
Project Start
2008-05-15
Project End
2013-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
5
Fiscal Year
2012
Total Cost
$121,770
Indirect Cost
$9,020
Name
University of California Los Angeles
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Rimoin, Anne W; Hoff, Nicole A; Fischer Walker, Christa L et al. (2011) Treatment of streptococcal pharyngitis with once-daily amoxicillin versus intramuscular benzathine penicillin G in low-resource settings: a randomized controlled trial. Clin Pediatr (Phila) 50:535-42
Fuller, Trevon; Thomassen, Henri A; Mulembakani, Prime M et al. (2011) Using remote sensing to map the risk of human monkeypox virus in the Congo Basin. Ecohealth 8:14-25
Djoko, Cyrille F; Rimoin, Anne W; Vidal, Nicole et al. (2011) High HIV type 1 group M pol diversity and low rate of antiretroviral resistance mutations among the uniformed services in Kinshasa, Democratic Republic of the Congo. AIDS Res Hum Retroviruses 27:323-9
Rimoin, Anne W; Mulembakani, Prime M; Johnston, Sara C et al. (2010) Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc Natl Acad Sci U S A 107:16262-7
Sharp, Colin P; Vermeulen, Marion; Nebie, Yacouba et al. (2010) Changing epidemiology of human parvovirus 4 infection in sub-Saharan Africa. Emerg Infect Dis 16:1605-7
Rimoin, Anne W; Walker, Christa L Fischer; Hamza, Hala S et al. (2010) The utility of rapid antigen detection testing for the diagnosis of streptococcal pharyngitis in low-resource settings. Int J Infect Dis 14:e1048-53
Pike, Brian L; Saylors, Karen E; Fair, Joseph N et al. (2010) The origin and prevention of pandemics. Clin Infect Dis 50:1636-40
Djoko, Cyrille F; Wolfe, Nathan D; Vidal, Nicole et al. (2010) HIV type 1 pol gene diversity and genotypic antiretroviral drug resistance mutations in Malabo, Equatorial Guinea. AIDS Res Hum Retroviruses 26:1027-31