This application is for a K01 Award for Dr. Helen Jenkins, a Research Fellow in the Global Health Equity Division at Brigham and Women's Hospital (BWH). Drug resistant strains of Mycobacterium tuberculosis (TB) threaten TB control. The detection and successful treatment of drug resistant TB (DR-TB) are compromised by the costly and time-consuming detection methods that are currently available in most settings. The severe under-estimation of this epidemic is a barrier to effective control. Undiagnosed DR-TB cases have poorer outcomes and may transmit disease for longer. Identifying hotspots of drug resistance is difficult when either access to or usage of drug susceptibility testing is limited, a in most settings. This project aims to develop methods for the spatial analysis of DR-TB data that account for geographic variation in diagnostic testing and allow identification of high DR-TB incidence. Datasets from two of the most concerning regions of the world with regard to DR-TB, Eastern Europe and sub-Saharan Africa, will be used.
The specific aims are: (A) Describe and understand heterogeneity and clustering of DR-TB in an area with high levels of diagnostics, (B) Develop methods for estimating DR-TB burden in an area with geographic heterogeneity in diagnostic use, (C) Describe and understand heterogeneity in DR-TB burden accounting for substantial geographic variation in diagnostic testing, (D) Identify risk factors fo the development and acquisition of drug resistance during TB treatment. This work will provide a methodological framework for analyzing similar datasets in these regions. The proposed project can help identify the mechanisms by which DR-TB emerges thus facilitating identification of interventions that ensure more patients receive timely and appropriate treatment and limit spread of resistant forms of disease. Dr. Jenkins'mentors will be Dr. Marcello Pagano, PhD, Professor of Statistical Computing in the Department of Biostatistics, Harvard School of Public Health (HSPH) whose research focuses on surveillance and statistical methods for infectious diseases and Dr. Ted Cohen, MD, MPH, DrPH, Assistant Professor of Epidemiology at HSPH and Associate Professor of Medicine at BWH who conducts research on TB epidemiology and DR-TB surveillance. Dr. Jenkins's advisory committee will include Dr. Marc Lipsitch, DPhil, Professor of Epidemiology at HSPH, Jeff Blossom, MSc, GIS expert at the Center for Geographic Analysis, Harvard University and Dr. Sonya Shin, MD, MPH, Associate Physician at BWH. Dr. Jenkins'training goals are (1) to become an expert in the analysis of spatial data and (2) obtain a solid understanding of the biology of infectious disease and she will take courses to achieve these. The research experience and training that Dr. Jenkins receives will provide her with the skills and preliminary data necessary to apply for R01 funding in the U.S. towards the end of the Award period. In the long-term, Dr. Jenkins aims to become an independent researcher developing and applying bio-statistical spatial methods in infectious disease epidemiology.

Public Health Relevance

Under-detection of drug-resistant tuberculosis (DR-TB) compromises the control of tuberculosis in areas where highly resistant forms of disease are emerging. The proposed research will develop methods to estimate DRTB incidence that account for spatial variation in drug susceptibility testing and thus facilitate the identificationof true DR-TB hot-spots. In turn, this will allow for investigation of local drivers of DR-TB, infor the design of control interventions, and ultimately ensure that more patients receive appropriate treatment.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Scientist Development Award - Research & Training (K01)
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Microbiology and Infectious Diseases B Subcommittee (MID)
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Jacobs, Gail G
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Brigham and Women's Hospital
United States
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Kunkel, Amber; Abel Zur Wiesch, Pia; Nathavitharana, Ruvandhi R et al. (2016) Smear positivity in paediatric and adult tuberculosis: systematic review and meta-analysis. BMC Infect Dis 16:282
Skrahin, Aliaksandr; Jenkins, Helen E; Hurevich, Henadz et al. (2016) Effectiveness of a novel cellular therapy to treat multidrug-resistant tuberculosis. J Clin Tuberc Other Mycobact Dis 4:21-27
Jenkins, Helen E (2016) Global Burden of Childhood Tuberculosis. Pneumonia (Nathan) 8:
Yuen, C M; Jenkins, H E; Chang, R et al. (2016) Two methods for setting child-focused tuberculosis care targets. Public Health Action 6:83-96
Jenkins, Helen E; Yuen, Courtney M; Rodriguez, Carly A et al. (2016) Mortality in children diagnosed with tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis :
Theron, Grant; Jenkins, Helen E; Cobelens, Frank et al. (2015) Data for action: collection and use of local data to end tuberculosis. Lancet 386:2324-33
Yuen, Courtney M; Jenkins, Helen E; Rodriguez, Carly A et al. (2015) Global and Regional Burden of Isoniazid-Resistant Tuberculosis. Pediatrics 136:e50-9
Seddon, J A; Jenkins, H E; Liu, L et al. (2015) Counting children with tuberculosis: why numbers matter. Int J Tuberc Lung Dis 19 Suppl 1:9-16
Jenkins, Helen E; Tolman, Arielle W; Yuen, Courtney M et al. (2014) Incidence of multidrug-resistant tuberculosis disease in children: systematic review and global estimates. Lancet 383:1572-9
Jenkins, Helen E; Crudu, Valeriu; Soltan, Viorel et al. (2014) High risk and rapid appearance of multidrug resistance during tuberculosis treatment in Moldova. Eur Respir J 43:1132-41

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