The candidate requests a five-year Mentored Career Development Award (K01) for training in the study of substance use and related problem behaviors in adolescence and emerging adulthood, and their relation to trajectories of adverse experiences in childhood (e.g., maltreatment, violence exposure, parental substance use). The candidate will also gain skills in the application of growth mixture models and other sophisticated latent variable techniques with large, multi-site, longitudinal datasets. The candidate's long-term goal is to integrate this training with her previous experience studying the childhood effects of maltreatment and violence exposure. Training includes coursework and close mentoring with experts in adolescence and emerging adulthood, substance use, problem behaviors, maltreatment, childhood adversity, and longitudinal latent variable analyses. The primary research goal is to examine pathways from multiple forms of maltreatment and co-occurring childhood adversities to subsequent substance use and problem behaviors (i.e., delinquency and sexual risk behaviors) using data from the five-site Consortium of Longitudinal Studies of Child Abuse and Neglect (LONGSCAN;total N = 1,354). Data from multiple informants collected every two years between the ages of 4 and 18 will be used to build growth mixture models to identify different trajectories of childhood adversity and adolescent substance use, delinquency, and sexual risk behaviors, and examine whether these trajectories are associated with one another. Once heterogeneity in trajectories has been modeled, mediating mechanisms for identified subgroups will be explored. Analyses will also explore the effects on results of using different measures of maltreatment and violence exposure (i.e., prospective county reports, retrospective self-report, and caregiver report). Child ethnicity, gender, and behavioral characteristics will also be examined as potential moderators of hypothesized relations. Proposed activities will inform development of an R01 proposal to follow the San Diego sample (n=330) into adulthood. Results will provide new information on longitudinal patterns of multiple adverse experiences and their relation to adolescent substance use and related problems. This knowledge will inform prevention efforts by increasing our knowledge of the role of specific dimensions of maltreatment and co-occurring adversities in the onset and development of adolescent substance use, delinquency, and sexual risk behavior.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01DA021674-06
Application #
8134897
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Weinberg, Naimah Z
Project Start
2007-04-23
Project End
2013-03-31
Budget Start
2011-04-01
Budget End
2013-03-31
Support Year
6
Fiscal Year
2011
Total Cost
$159,312
Indirect Cost
Name
Judge Baker Children's Center
Department
Type
DUNS #
073824922
City
Boston
State
MA
Country
United States
Zip Code
02120
Lewis, Terri; Thompson, Richard; Kotch, Jonathan B et al. (2013) Correlates of parent-youth discordance about youth-witnessed violence: a brief report. Violence Vict 28:865-74
Flaherty, Emalee G; Thompson, Richard; Dubowitz, Howard et al. (2013) Adverse childhood experiences and child health in early adolescence. JAMA Pediatr 167:622-9
Jones, Deborah J; Lewis, Terri; Litrownik, Alan et al. (2013) Linking childhood sexual abuse and early adolescent risk behavior: the intervening role of internalizing and externalizing problems. J Abnorm Child Psychol 41:139-50
Thompson, Richard; Proctor, Laura J; English, Diana J et al. (2012) Suicidal ideation in adolescence: examining the role of recent adverse experiences. J Adolesc 35:175-86
Proctor, Laura J; Aarons, Gregory A; Dubowitz, Howard et al. (2012) Trajectories of maltreatment re-reports from ages 4 to 12:: evidence for persistent risk after early exposure. Child Maltreat 17:207-17
Thompson, Richard; Litrownik, Alan J; Isbell, Patricia et al. (2012) Adverse Experiences and Suicidal Ideation in Adolescence: Exploring the Link Using the LONGSCAN Samples. Psychol Violence 2:
Lewis, Terri; Thompson, Richard; Kotch, Jonathan B et al. (2012) Parent-youth discordance about youth-witnessed violence: associations with trauma symptoms and service use in an at-risk sample. Child Abuse Negl 36:790-7
Proctor, Laura J; Van Dusen Randazzo, Katherine; Litrownik, Alan J et al. (2011) Factors associated with caregiver stability in permanent placements: a classification tree approach. Child Abuse Negl 35:425-36
Oberlander, Sarah E; Wang, Yan; Thompson, Richard et al. (2011) Childhood maltreatment, emotional distress, and early adolescent sexual intercourse: multi-informant perspectives on parental monitoring. J Fam Psychol 25:885-94
Lewis, Terri; Kotch, Jonathan; Thompson, Richard et al. (2010) Witnessed violence and youth behavior problems: a multi-informant study. Am J Orthopsychiatry 80:443-50

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