This is a revised application for a K01 to launch an independent research program on the use of Therapeutic Interactive Voice Response (TIVR) and other computer-assisted methods to provide drug counseling to patients receiving office-based buprenorphine maintenance and other drug abuse treatment. This application builds on my expertise in cognitive psychology, computer technologies, drug counseling, drug treatment in primary care settings, and statistics, and takes advantage of the unique resources at Yale. A K01 would provide salary support at a critical juncture in my career, free me up from other projects, and allow me to devote 100% toward becoming an independent investigator. For my training, the K01 would allow me to increase my skills and knowledge in 3 areas: 1) computer based interventions for substance abuse and other psychiatric disorders, 2) the development and evaluation of manual-guided behavioral interventions, and 3) qualitative research methods. For my independent research, I propose to conduct a research project in 3 phases to develop and evaluate a TIVR prototype providing cognitive and behavioral treatment (CBT) to opioid dependent patients receiving buprenorpine maintenance in a primary care setting. The three research phases will involve the generation, testing, and modification of TIVR individual treatment modules. Phase 1 will involve feasibility testing of 10 generated modules across 4 iterations. Phase 2 will compare a single module/session of the TIVR system to an educational video presentation condition and a single therapist-provided session on proximal outcomes of effectiveness among opiate-dependent patients initiating buprenorphine treatment (n = 60). Phase 3 will consist of a pilot trial of TIVR for buprenorphine maintained patients in a primary care setting. Forty patients will be randomly assigned to either TIVR, receiving access to the 10 module prototype for 4 weeks, or to treatment-as-usual. This pilot will provide initial evidence of TIVR efficacy and indicators of the feasibility and acceptability of using TIVR in office-based settings.

Public Health Relevance

Development of an effective, inexpensive, and easily accessible computer based CBT for drug abuse patients in primary care settings would greatly expand and improve available substance abuse services.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Scientist Development Award - Research & Training (K01)
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Application #
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Grossman, Debra
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Yale University
Schools of Medicine
New Haven
United States
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Barry, Declan T; Fazzino, Tera; Necrason, Emily et al. (2016) The Availability of Ancillary Counseling in the Practices of Physicians Prescribing Buprenorphine. J Addict Med 10:352-6
Fiellin, David A; Schottenfeld, Richard S; Cutter, Christopher J et al. (2014) Primary care-based buprenorphine taper vs maintenance therapy for prescription opioid dependence: a randomized clinical trial. JAMA Intern Med 174:1947-54
Cutter, Christopher J; Schottenfeld, Richard S; Moore, Brent A et al. (2014) A pilot trial of a videogame-based exercise program for methadone maintained patients. J Subst Abuse Treat 47:299-305
Barry, Declan T; Savant, Jonathan D; Beitel, Mark et al. (2014) The feasibility and acceptability of groups for pain management in methadone maintenance treatment. J Addict Med 8:338-44
Fiellin, David A; Barry, Declan T; Sullivan, Lynn E et al. (2013) A randomized trial of cognitive behavioral therapy in primary care-based buprenorphine. Am J Med 126:74.e11-7
Barry, Declan T; Savant, Jonathan D; Beitel, Mark et al. (2013) Pain and associated substance use among opioid dependent individuals seeking office-based treatment with buprenorphine-naloxone: a needs assessment study. Am J Addict 22:212-7
Moore, Brent A; Fazzino, Tera; Barry, Declan T et al. (2013) The Recovery Line: A pilot trial of automated, telephone-based treatment for continued drug use in methadone maintenance. J Subst Abuse Treat 45:63-9
Moore, Brent A; Barry, Declan T; Sullivan, Lynn E et al. (2012) Counseling and directly observed medication for primary care buprenorphine maintenance: a pilot study. J Addict Med 6:205-11
Barry, Declan T; Savant, Jonathan D; Beitel, Mark et al. (2012) Use of conventional, complementary, and alternative treatments for pain among individuals seeking primary care treatment with buprenorphine-naloxone. J Addict Med 6:274-9
Edelman, E Jennifer; Dinh, An T; Moore, Brent A et al. (2012) Human immunodeficiency virus testing practices among buprenorphine-prescribing physicians. J Addict Med 6:159-65

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