The desire to pursue a career as a neuroimaging researcher evolved from my longstanding interest in the biologic mechanisms associated with substance induced brain injury. My most productive substance abuse research has been with Dr. Dieter Meyerhoff, Professor of Radiology at the University of California San Francisco (UCSF), on a study of the neurobiological mechanisms associated with alcoholism-related brain injury. As Assistant Professor at UCSF, I am responsible for all neurocognitive and psychiatric assessment. However, I am currently unable to independently apply the MR acquisition or processing methodology to my own research interests, due to a lack of specific training in this area. My overarching career goal is to develop programmatic research that will advance our understanding of the neurobiological mechanisms associated with cognitive dysfunction in substance use disorders, with an emphasis on under-represented minorities. To realize this goal, I will require focused training in: 1) the acquisition, processing, and interpretation of advanced magnetic resonance neuroimaging methods;2) the neurobiological and cognitive implications of nicotine dependence;3) clinical assessment methods for nicotine dependence;4) advanced statistical methodology;5) advanced neuroanatomy and neurophysiology. Dr. Meyerhoff and a panel of experts will provide me with extensive training in these areas, complemented by relevant seminars and courses. My research plan will combine state-of-the art resonance imaging techniques and comprehensive neurocognitive testing to better elucidate the effects of chronic smoking on human neurobiology and function. I will use this award to develop into a productive researcher who is in the unique position to combine in-vivo magnetic resonance-based techniques, with expertise in clinical neuropsychology, to examine the neurobiological and cognitive effects of substance use disorders.

Public Health Relevance

It is well known that cigarette smoking harms nearly every organ of the body and it is linked to many diseases. However, little is known about how smoking affects a very important organ - the human brain. This study will use advanced neuroimaging techniques and cognitive tests to better understand the effects of smoking on the brain and its functions. Such information may help develop better medications and behavioral treatments to assist with the millions around the world who are unable to quit smoking.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01DA024136-03
Application #
7858127
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Kautz, Mary A
Project Start
2008-08-15
Project End
2013-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
3
Fiscal Year
2010
Total Cost
$158,476
Indirect Cost
Name
University of California San Francisco
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Durazzo, Timothy C; Murray, Donna E; Meyerhoff, Dieter J (2017) Reply to: On the Correction of Effects of Flip Angle in (1)H Magnetic Resonance Spectroscopy Signal Acquired Using Stimulated Echo Acquisition Mode Sequence. Biol Psychiatry 81:e17
Murray, Donna E; Durazzo, Timothy C; Schmidt, Thomas P et al. (2017) Regional cerebral blood flow in opiate dependence relates to substance use and neuropsychological performance. Addict Biol :
Zou, Yukai; Murray, Donna E; Durazzo, Timothy C et al. (2017) Effects of abstinence and chronic cigarette smoking on white matter microstructure in alcohol dependence: Diffusion tensor imaging at 4T. Drug Alcohol Depend 175:42-50
Durazzo, Timothy C; Meyerhoff, Dieter J (2017) Psychiatric, Demographic, and Brain Morphological Predictors of Relapse After Treatment for an Alcohol Use Disorder. Alcohol Clin Exp Res 41:107-116
Schmidt, Thomas P; Pennington, David L; Cardoos, Stephanie L et al. (2017) Neurocognition and inhibitory control in polysubstance use disorders: Comparison with alcohol use disorders and changes with abstinence. J Clin Exp Neuropsychol 39:22-34
Durazzo, Timothy C; Mattsson, Niklas; Weiner, Michael W et al. (2016) Interaction of Cigarette Smoking History With APOE Genotype and Age on Amyloid Level, Glucose Metabolism, and Neurocognition in Cognitively Normal Elders. Nicotine Tob Res 18:204-11
Durazzo, Timothy C; Korecka, Magdalena; Trojanowski, John Q et al. (2016) Active Cigarette Smoking in Cognitively-Normal Elders and Probable Alzheimer's Disease is Associated with Elevated Cerebrospinal Fluid Oxidative Stress Biomarkers. J Alzheimers Dis 54:99-107
Durazzo, Timothy C; Meyerhoff, Dieter J; Mon, Anderson et al. (2016) Chronic Cigarette Smoking in Healthy Middle-Aged Individuals Is Associated With Decreased Regional Brain N-acetylaspartate and Glutamate Levels. Biol Psychiatry 79:481-8
Murray, Donna E; Durazzo, Timothy C; Schmidt, Thomas P et al. (2016) Frontal Metabolite Concentration Deficits in Opiate Dependence Relate to Substance Use, Cognition, and Self-Regulation. J Addict Res Ther 7:
Durazzo, Timothy C; Mon, Anderson; Gazdzinski, Stefan et al. (2015) Serial longitudinal magnetic resonance imaging data indicate non-linear regional gray matter volume recovery in abstinent alcohol-dependent individuals. Addict Biol 20:956-67

Showing the most recent 10 out of 40 publications