This K01 award will allow the candidate, Dr. Sarah Messiah, to gain the skills, knowledge and experience required to become an independent investigator. Using data from the Miami Prenatal Cocaine Study (MFCS, Dr. Emmalee Bandstra, Principal Investigator), Dr. Messiah will examine the relationship between in utero cocaine exposure, anthropometric growth and development of cardiometabolic disease risk factors in African American children at ages 16-18. The MPCS has collected 11 prior waves of multi-domain data on over 400 infants and their mothers/alternate caregivers through early adolescence and is now embarking on 2 additional waves of data collection at ages 16 -18 years. The proposed mentored research has three specific aims: (1) To longitudinally compare anthropometric measures (height, weight, body mass index, waist circumference, and body composition) among urban, African American children and adolescents who were or were not prenatally exposed to cocaine using a previously established and well-characterized NIDA cohort;(2) To compare cardiometabolic risk factors (fasting glucose, insulin, lipids, CRP, blood pressure) cross-sectionally among urban, African American adolescents who were or were not exposed prenatally to cocaine using a previously established and well-characterized NIDA cohort;and (3) To determine the specific effects of both prenatal and postnatal exposures of cocaine in a repeated measures multivariate analysis, controlling for effect modifiers (nicotine, alcohol and marijuana exposure, stress, anxiety and depression in children and mothers) on: (a) Overweight and obesity, (b) Underweight, and (c) >3 cardiometabolic risk factors (often referred to as "metabolic syndrome"). To achieve this research and her career development goals, Dr. Messiah will follow a career development plan at the University of Miami Miller School of Medicine, designed to provide knowledge, skills, and experience in 4 core competencies (hfe course of disease, with particular emphasis on in utero cocaine exposure, longitudinal/latent growth analytical methods, embryology, and cardiometabolic disease risk factor development in childhood and subsequent risk for adult onset chronic disease). The broad, long-term goal of the proposed research is to elucidate causal and non-causal links with a specific focus upon how in utero cocaine exposure might alter the occurrence and trajectories of anthropometric grovrth, and subsequent development of cardiometabolic disease risk factors. Findings from this investigation should inform both the fields of substance use and cardiovascular research about subsequent risks of cocaine ingestion during pregnancy in offspring.

Public Health Relevance

This study will provide important latency affect analysis of the long-term cardiovascular health implications among in utero cocaine exposed children. Findings from this investigation should inform both the fields of substance use and cardiovascular research about subsequent risks of cocaine ingestion during pregnancy in offspring.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01DA026993-05
Application #
8477162
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Khalsa, Jagjitsingh H
Project Start
2009-08-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2013
Total Cost
$167,508
Indirect Cost
$12,408
Name
University of Miami School of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
052780918
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
Vidot, Denise C; Prado, Guillermo; Hlaing, WayWay M et al. (2016) Metabolic Syndrome Among Marijuana Users in the United States: An Analysis of National Health and Nutrition Examination Survey Data. Am J Med 129:173-9
Vidot, Denise C; Prado, Guillermo; De La Cruz-Munoz, Nestor et al. (2016) Postoperative marijuana use and disordered eating among bariatric surgery patients. Surg Obes Relat Dis 12:171-8
Vidot, Denise C; Messiah, Sarah E; Prado, Guillermo et al. (2016) Relationship Between Current Substance Use and Unhealthy Weight Loss Practices Among Adolescents. Matern Child Health J 20:870-7
Messiah, Sarah E; Ludwig, David A; Vidot, Denise C et al. (2015) Prenatal Cocaine Exposure and Cardiometabolic Disease Risk Factors in 18- to 20-Year-Old African Americans. Ethn Dis 25:419-26
Gurnurkar, Shilpa; Arheart, Kristopher L; Messiah, Sarah E et al. (2014) Skeletal maturation and predicted adult height in children with premature adrenarche. J Pediatr Endocrinol Metab 27:69-74
Vidot, Denise C; Prado, Guillermo; Hlaing, WayWay M et al. (2014) Emerging issues for our nation's health: the intersection of marijuana use and cardiometabolic disease risk. J Addict Dis 33:1-8
Messiah, Sarah E; Vidot, Denise C; Gurnurkar, Shilpa et al. (2014) Obesity is significantly associated with cardiovascular disease risk factors in 2- to 9-year-olds. J Clin Hypertens (Greenwich) 16:889-94
Vidot, D C; Arheart, K L; Prado, G et al. (2013) Illicit drug use and cardiometabolic disease risk: an analysis of 2005-2008 National Health and Nutrition Examination Survey data. Int J Clin Pract 67:1173-81
Messiah, Sarah E; Lopez-Mitnik, Gabriela; Winegar, Deborah et al. (2013) Effect of ethnicity on weight loss among adolescents 1 year after bariatric surgery. World J Diabetes 4:202-9
De La Cruz-Munoz, Nestor; Lopez-Mitnik, Gabriela; Arheart, Kristopher L et al. (2013) Effectiveness of bariatric surgery in reducing weight and body mass index among Hispanic adolescents. Obes Surg 23:150-6

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