Recent data indicate substantial health disparities in lesbian, gay, and bisexual (LGB) populations, including nearly twice the risk of substance use among LGB youths compared to their heterosexual peers. Additionally, young gay/bisexual men, already disproportionately burdened with HIV morbidity, are one of the only risk groups in which new HIV infection rates are increasing. A 2011 report on LGB health released by the Institute of Medicine (IOM) noted the dearth of research on the factors responsible for these disparities. This report identified the study of social ecological influences as a priority researc area, and emphasized the need for studies that adopt minority stress and life course perspectives in order to determine how the unique issues confronting LGB populations increase their risk for adverse health outcomes. This Mentored Research Scientist Development Award (K01) will provide the candidate with the protected time, training, and resources necessary to carry out these research priorities established in the IOM report. The goal of the Award is to develop an interdisciplinary research program focused on identifying modifiable social ecological factors that can explain and address health disparities among LGB youth. To accomplish his career goals and research objectives, the candidate requires training and mentorship in social epidemiology, biostatistical approaches to life course studies, and stress biology. This training will be accomplished through a combination of mentored research projects, courses, seminars, and conferences. The new skills that are acquired will enable the candidate to conduct innovative, high-impact research examining how and why the social environment surrounding LGB youth contributes to their increased risk for substance use and associated problems. The over-arching objectives of this research are: (1) to evaluate whether sexual minority stress measured at the social ecological level predicts substance use and HIV risk behaviors within LGB youth and explains sexual orientation-related disparities in these outcomes;(2) to identify modifiable contextual factors that protect LGB youth from engaging in substance use and HIV risk behaviors;and (3) to elucidate biological pathways that mediate the relationship between sexual minority stress, substance use, and HIV risk behaviors. This proposal uses a multi-method framework that draws on the strengths of two prospective cohort studies (the Growing Up Today Study and the National Longitudinal Study of Adolescent Health) that have followed LGB and heterosexual adolescents for over 15 years. These epidemiologic studies will be complemented by data collection in two studies that utilize experimental and experience-sampling designs. This research will address novel questions about social determinants of LGB health, their interplay with individual biological factors, and how these processes emerge over the life course. Moreover, the results will facilitate the development of structural, policy, and community-level interventions that reduce sexual orientation-related disparities in substance use and HIV risk behaviors, an important priority at NIDA.

Public Health Relevance

Given the persistence of substantial health disparities in lesbian, gay, and bisexual (LGB) populations compared to heterosexuals, research into the underlying factors that can explain these disparities constitutes a critical area for public health Chronic exposure to sexual minority stress during adolescence may contribute to elevated rates of substance use and HIV risk behaviors among LGB youth, resulting in deleterious health outcomes as well as considerable economic and societal costs. The goal of this proposed research is to identify modifiable social determinants of substance use and HIV risk behaviors among LGB youth that can be used to develop public health interventions that reduce health disparities within this vulnerable population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01DA032558-02
Application #
8507701
Study Section
Special Emphasis Panel (ZDA1-NXR-B (14))
Program Officer
Schulden, Jeffrey D
Project Start
2012-09-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
2
Fiscal Year
2013
Total Cost
$178,173
Indirect Cost
$13,198
Name
Columbia University (N.Y.)
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Hatzenbuehler, Mark L (2016) Structural stigma: Research evidence and implications for psychological science. Am Psychol 71:742-751
Oldenburg, Catherine E; Perez-Brumer, Amaya G; Reisner, Sari L et al. (2016) Human rights protections and HIV prevalence among MSM who sell sex: Cross-country comparisons from a systematic review and meta-analysis. Glob Public Health :1-12
Coulter, Robert W S; Birkett, Michelle; Corliss, Heather L et al. (2016) Associations between LGBTQ-affirmative school climate and adolescent drinking behaviors. Drug Alcohol Depend 161:340-7
Pachankis, John E; Hatzenbuehler, Mark L; Mirandola, Massimo et al. (2016) The Geography of Sexual Orientation: Structural Stigma and Sexual Attraction, Behavior, and Identity Among Men Who Have Sex with Men Across 38 European Countries. Arch Sex Behav :
Bränström, Richard; Hatzenbuehler, Mark L; Pachankis, John E et al. (2016) Sexual Orientation Disparities in Preventable Disease: A Fundamental Cause Perspective. Am J Public Health 106:1109-15
Pachankis, John E; Hatzenbuehler, Mark L; Hickson, Ford et al. (2015) Hidden from health: structural stigma, sexual orientation concealment, and HIV across 38 countries in the European MSM Internet Survey. AIDS 29:1239-46
Perez-Brumer, Amaya; Hatzenbuehler, Mark L; Oldenburg, Catherine E et al. (2015) Individual- and Structural-Level Risk Factors for Suicide Attempts Among Transgender Adults. Behav Med 41:164-71
Hatzenbuehler, Mark L; Jun, Hee-Jin; Corliss, Heather L et al. (2015) Structural stigma and sexual orientation disparities in adolescent drug use. Addict Behav 46:14-8
Juster, Robert-Paul; Hatzenbuehler, Mark L; Mendrek, Adrianna et al. (2015) Sexual orientation modulates endocrine stress reactivity. Biol Psychiatry 77:668-76
Hatzenbuehler, Mark L; McLaughlin, Katie A; Xuan, Ziming (2015) Social networks and sexual orientation disparities in tobacco and alcohol use. J Stud Alcohol Drugs 76:117-26

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