Recent data indicate substantial health disparities in lesbian, gay, and bisexual (LGB) populations, including nearly twice the risk of substance use among LGB youths compared to their heterosexual peers. Additionally, young gay/bisexual men, already disproportionately burdened with HIV morbidity, are one of the only risk groups in which new HIV infection rates are increasing. A 2011 report on LGB health released by the Institute of Medicine (IOM) noted the dearth of research on the factors responsible for these disparities. This report identified the study of social ecological influences as a priority researc area, and emphasized the need for studies that adopt minority stress and life course perspectives in order to determine how the unique issues confronting LGB populations increase their risk for adverse health outcomes. This Mentored Research Scientist Development Award (K01) will provide the candidate with the protected time, training, and resources necessary to carry out these research priorities established in the IOM report. The goal of the Award is to develop an interdisciplinary research program focused on identifying modifiable social ecological factors that can explain and address health disparities among LGB youth. To accomplish his career goals and research objectives, the candidate requires training and mentorship in social epidemiology, biostatistical approaches to life course studies, and stress biology. This training will be accomplished through a combination of mentored research projects, courses, seminars, and conferences. The new skills that are acquired will enable the candidate to conduct innovative, high-impact research examining how and why the social environment surrounding LGB youth contributes to their increased risk for substance use and associated problems. The over-arching objectives of this research are: (1) to evaluate whether sexual minority stress measured at the social ecological level predicts substance use and HIV risk behaviors within LGB youth and explains sexual orientation-related disparities in these outcomes;(2) to identify modifiable contextual factors that protect LGB youth from engaging in substance use and HIV risk behaviors;and (3) to elucidate biological pathways that mediate the relationship between sexual minority stress, substance use, and HIV risk behaviors. This proposal uses a multi-method framework that draws on the strengths of two prospective cohort studies (the Growing Up Today Study and the National Longitudinal Study of Adolescent Health) that have followed LGB and heterosexual adolescents for over 15 years. These epidemiologic studies will be complemented by data collection in two studies that utilize experimental and experience-sampling designs. This research will address novel questions about social determinants of LGB health, their interplay with individual biological factors, and how these processes emerge over the life course. Moreover, the results will facilitate the development of structural, policy, and community-level interventions that reduce sexual orientation-related disparities in substance use and HIV risk behaviors, an important priority at NIDA.

Public Health Relevance

Given the persistence of substantial health disparities in lesbian, gay, and bisexual (LGB) populations compared to heterosexuals, research into the underlying factors that can explain these disparities constitutes a critical area for public health Chronic exposure to sexual minority stress during adolescence may contribute to elevated rates of substance use and HIV risk behaviors among LGB youth, resulting in deleterious health outcomes as well as considerable economic and societal costs. The goal of this proposed research is to identify modifiable social determinants of substance use and HIV risk behaviors among LGB youth that can be used to develop public health interventions that reduce health disparities within this vulnerable population.

National Institute of Health (NIH)
Research Scientist Development Award - Research & Training (K01)
Project #
Application #
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Schulden, Jeffrey D
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Columbia University (N.Y.)
Public Health & Prev Medicine
Schools of Public Health
New York
United States
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Hatzenbuehler, Mark L; Keyes, Katherine M; Hamilton, Ava et al. (2014) State-level tobacco environments and sexual orientation disparities in tobacco use and dependence in the USA. Tob Control 23:e127-32
Duncan, Dustin T; Hatzenbuehler, Mark L (2014) Lesbian, gay, bisexual, and transgender hate crimes and suicidality among a population-based sample of sexual-minority adolescents in Boston. Am J Public Health 104:272-8
Lukachko, Alicia; Hatzenbuehler, Mark L; Keyes, Katherine M (2014) Structural racism and myocardial infarction in the United States. Soc Sci Med 103:42-50
Hatzenbuehler, Mark L; McLaughlin, Katie A (2014) Structural stigma and hypothalamic-pituitary-adrenocortical axis reactivity in lesbian, gay, and bisexual young adults. Ann Behav Med 47:39-47
Hatzenbuehler, Mark L; Birkett, Michelle; Van Wagenen, Aimee et al. (2014) Protective school climates and reduced risk for suicide ideation in sexual minority youths. Am J Public Health 104:279-86
Mustanski, Brian; Birkett, Michelle; Greene, George J et al. (2014) Envisioning an America without sexual orientation inequities in adolescent health. Am J Public Health 104:218-25
Hatzenbuehler, Mark L; Slopen, Natalie; McLaughlin, Kate A (2014) Stressful life events, sexual orientation, and cardiometabolic risk among young adults in the United States. Health Psychol 33:1185-94
Hatzenbuehler, Mark L; Bellatorre, Anna; Lee, Yeonjin et al. (2014) Structural stigma and all-cause mortality in sexual minority populations. Soc Sci Med 103:33-41
Burton, C L; Bonanno, G A; Hatzenbuehler, M L (2014) Familial social support predicts a reduced cortisol response to stress in sexual minority young adults. Psychoneuroendocrinology 47:241-5
Hatzenbuehler, Mark L; Jun, Hee-Jin; Corliss, Heather L et al. (2014) Structural stigma and cigarette smoking in a prospective cohort study of sexual minority and heterosexual youth. Ann Behav Med 47:48-56

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