The goal of this career development plan is to launch an independent research career in children's environmental health, with a particular focus on environmental toxicants and child neurobehavioral development. Some industrial chemicals, most notably lead and methylmercury (CH3Hg), are recognized causes of neurodevelopmental disorders and subclinical brain dysfunction. The developing fetus and young children are particularly susceptible to environmental insults, but investigations of the effects of prenatal and early childhood exposure to most chemicals are limited. This career development plan will build on the candidate's formal training in epidemiology to obtain the background in environmental toxicology needed to develop hypotheses and design environmental neuroepidemiology studies that are well-grounded in biological mechanisms of toxicity. This plan incorporates didactic training in environmental toxicology and molecular epidemiology, practical training in the use of biomarkers of exposure and neurobehavioral assessments in epidemiologic research, and additional training in complex statistical techniques. The research component builds on the Study of C8 and Neurobehavioral Development, an ongoing study of 550 children in a region of the Mid-Ohio Valley subjected to perfluorooctanoic acid and other industrial pollutants. The knowledge, skills, and experience gained through the training portion of this career development plan will be applied to examine the associations of biomarkers of exposure to perfluorinated compounds, manganese, and arsenic with child neurobehavioral development at ages 6 to 11. The candidate is an Instructor in the Department of Preventive Medicine at Mount Sinai School of Medicine, a nationally and internationally recognized center of excellence in preventive medicine, occupational and environmental medicine, community health, and environmental pediatrics. An interdisciplinary mentorship team has been selected to provide guidance and expertise in environmental toxicology, environmental epidemiology, and child neurobehavioral development. Fulfillment of this career development plan will enable the candidate to critically appraise the state of knowledge on environmental toxicants, to recognize the most promising substantive directions for future research, to select contextually appropriate markers of exposure and outcome, and ultimately to identify populations especially vulnerable to environmental toxicants. The proposed training and research program will position the candidate to work effectively with a number of active, multidisciplinary groups at the completion of the award period. Moreover, this career development plan will facilitate the candidate becoming, in time, a leading expert and independent investigator in children's environmental health.

Public Health Relevance

The developing fetus and young children are particularly susceptible to environmental insults, but investigations of the effects of prenatal and early childhood exposure to most chemicals are limited and susceptible to distinct methodologic challenges. This proposed project can significantly impact the health and welfare of a vulnerable population by describing the association between three potentially preventable exposures and child neurobehavioral development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01ES019156-04
Application #
8462265
Study Section
Special Emphasis Panel (ZES1-LWJ-V (01))
Program Officer
Shreffler, Carol K
Project Start
2010-09-01
Project End
2015-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
4
Fiscal Year
2013
Total Cost
$129,465
Indirect Cost
$9,590
Name
Icahn School of Medicine at Mount Sinai
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Stein, Cheryl R; Savitz, David A; Bellinger, David C (2014) Perfluorooctanoate exposure in a highly exposed community and parent and teacher reports of behaviour in 6-12-year-old children. Paediatr Perinat Epidemiol 28:146-56
Stein, Cheryl R; Savitz, David A; Elston, Beth et al. (2014) Perfluorooctanoate exposure and major birth defects. Reprod Toxicol 47:15-20
Barria, Maria Ines; Garrido, Jose Luis; Stein, Cheryl et al. (2013) Localized mucosal response to intranasal live attenuated influenza vaccine in adults. J Infect Dis 207:115-24
Darrow, Lyndsey A; Stein, Cheryl R; Steenland, Kyle (2013) Serum perfluorooctanoic acid and perfluorooctane sulfonate concentrations in relation to birth outcomes in the Mid-Ohio Valley, 2005-2010. Environ Health Perspect 121:1207-13
Stein, Cheryl R; Savitz, David A; Bellinger, David C (2013) Perfluorooctanoate and neuropsychological outcomes in children. Epidemiology 24:590-9
Savitz, David A; Stein, Cheryl R; Bartell, Scott M et al. (2012) Perfluorooctanoic acid exposure and pregnancy outcome in a highly exposed community. Epidemiology 23:386-92
Mondal, Debapriya; Lopez-Espinosa, Maria-Jose; Armstrong, Ben et al. (2012) Relationships of perfluorooctanoate and perfluorooctane sulfonate serum concentrations between mother-child pairs in a population with perfluorooctanoate exposure from drinking water. Environ Health Perspect 120:752-7
Stein, Cheryl R; Savitz, David A (2011) Serum perfluorinated compound concentration and attention deficit/hyperactivity disorder in children 5-18 years of age. Environ Health Perspect 119:1466-71