This project is designed to train to independence Bernadette Gillick, PhD, MSPT, PT as a rehabilitation scientist and to advance rehabilitation research in children with neurologic deficits. Dr. Gillick is a developing rehabilitation scientist with over two decades of clinical experience;with research interest both in the reorganization of the developing brain after neurologic insult or injury, and in the influence of electrophysiologic and behavioral interventions on neurorecovery. Dr. Gillick's career development objectives include expanding her knowledge of running clinical trials, mastering techniques to investigate brain reorganization and creating novel interventions designed to enhance functional motor recovery. Since last submission, Dr. Gillick has reassembled a comprehensive team of mentors and a research advisory committee to direct and guide her training. The training plan includes formal meetings with mentors, didactic training with a Certificate in Clinical Research, national meeting presentations, preparation of grant applications and manuscripts. The research project takes Dr. Gillick's work in a direction not yet studied-the use of a novel form of non-invasive brain stimulation in pediatric rehabilitation. Through her prior experience, she has learned that electrophysiologic and behavioral interventions can have a beneficial synergistic effect. She has also recently completed a safety pilot in the use of a novel form of non-invasive brain stimulation. Based on these promising findings Dr. Gillick proposes to combine interventions that, with a more thorough understanding of their effects, can conveniently reach the clinical setting and will cost less. The integration of this novel rehabilitation approach may lead to improved motor function for individuals throughout their lifetimes. The advanced support provided by the K01 career development training and research of Dr. Gillick will contribute to the NIH by producing an independent scientist able to conduct clinically relevant and translational research in pediatric neurorecovery.
This proposal is constructed to train and develop Bernadette Gillick, PhD, MSPT, PT to be a rehabilitation scientist in the field of pediatric neurorehabilitatin and neurorecovery. Her training will result in establishing an independent scientist performing translational research that has the promise to result in novel interventions in pediatric neurorecovery.
|Gillick, Bernadette; Rich, Tonya; Nemanich, Samuel et al. (2018) Transcranial direct current stimulation and constraint-induced therapy in cerebral palsy: A randomized, blinded, sham-controlled clinical trial. Eur J Paediatr Neurol 22:358-368|
|Chen, Chao-Ying; McGee, Corey W; Rich, Tonya L et al. (2018) Reference values of intrinsic muscle strength of the hand of adolescents and young adults. J Hand Ther 31:348-356|
|Rich, Tonya L; Menk, Jeremiah S; Rudser, Kyle D et al. (2017) Determining Electrode Placement for Transcranial Direct Current Stimulation: A Comparison of EEG- Versus TMS-Guided Methods. Clin EEG Neurosci 48:367-375|
|Rich, Tonya L; Menk, Jeremiah S; Rudser, Kyle D et al. (2017) Less-Affected Hand Function in Children With Hemiparetic Unilateral Cerebral Palsy: A Comparison Study With Typically Developing Peers. Neurorehabil Neural Repair 31:965-976|
|Rich, Tonya L; Menk, Jeremiah; Krach, Linda E et al. (2016) Repetitive Transcranial Magnetic Stimulation/Behavioral Intervention Clinical Trial: Long-Term Follow-Up of Outcomes in Congenital Hemiparesis. J Child Adolesc Psychopharmacol 26:598-605|
|Bikson, Marom; Grossman, Pnina; Thomas, Chris et al. (2016) Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016. Brain Stimul 9:641-661|
|Chen, Chao-Ying; Rich, Tonya L; Cassidy, Jessica M et al. (2016) Corticospinal Excitability in Children with Congenital Hemiparesis. Brain Sci 6:|
|Gillick, Bernadette T; Rich, Tonya; Chen, Mo et al. (2015) Case report of vasovagal syncope associated with single pulse transcranial magnetic stimulation in a healthy adult participant. BMC Neurol 15:248|
|Gillick, Bernadette; Menk, Jeremiah; Mueller, Bryon et al. (2015) Synergistic effect of combined transcranial direct current stimulation/constraint-induced movement therapy in children and young adults with hemiparesis: study protocol. BMC Pediatr 15:178|