This is Dr. Cheryl Anderson's application for a NHLBI Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01). Cheryl Anderson, PhD, MPH is a nutritional epidemiologist and has a faculty position as an Assistant Scientist in the department of Epidemiology at the Johns Hopkins University Bloomberg School of Public Health (Hopkins). Dr. Anderson's research interests center around nutrition as a means to prevent cardiovascular disease (CVD) in minority and underserved populations. Her long-term goal is to combine her interdisciplinary training in health behavior, epidemiology and nutritional sciences to conduct observational and clinical studies of CVD. In this application, Dr. Anderson outlines a career development and research plan that provides critical new scientific skills and extend her research capabilities, to enhance her development into an independent scientist. Lawrence Appel, MD, MPH will mentor Dr. Anderson in the proposed research. Dr. Appel is a recognized expert in CVD prevention through both pharmacologic and non-pharmacologic (diet) approaches. He is a professor of medicine, epidemiology and international health (nutrition) at the Johns Hopkins Medical Institutions. Dr. Anderson has also assembled an advisory committee of accomplished researchers to provide scientific and career development advice, as well as evaluate her progress. The objectives of Dr. Anderson's research plan are to examine the main and interactive effects of dietary sodium and potassium intake (measured by 24-hour urinary excretion) on echocardiographic left ventricular (LV) mass and clinical CVD. Her research will be conducted within the context of the NIH-funded African American Study of Kidney Disease and Hypertension (AASK) study. She will use do secondary analyses of data from both the AASK trial and AASK cohort study. The ongoing AASK cohort study is a prospective, observational study that is an extension of the AASK trial which tested the effects of three anti-hypertensive therapies and two levels of blood pressure control on progression of kidney disease. Dr. Anderson will also conduct additional (de-novo) data collection, in a subcohort of AASK, to characterize the sources of dietary sodium and potassium in the cohort - a highly relevant clinical issue. Dr. Anderson is in a supportive institutional environment at Hopkins that maximizes her potential to establish an independent, competitive research agenga that will support a prolific academic career.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Scientist Development Award - Research & Training (K01)
Project #
5K01HL092595-05
Application #
8240478
Study Section
Special Emphasis Panel (ZHL1-CSR-G (F1))
Program Officer
Arteaga, Sonia M
Project Start
2008-04-01
Project End
2012-08-31
Budget Start
2012-04-01
Budget End
2012-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$57,945
Indirect Cost
$4,292
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Anderson, Cheryl A M; Cobb, Laura K; Miller 3rd, Edgar R et al. (2015) Effects of a behavioral intervention that emphasizes spices and herbs on adherence to recommended sodium intake: results of the SPICE randomized clinical trial. Am J Clin Nutr 102:671-9
Fakhouri, Tala H I; Jahren, A Hope; Appel, Lawrence J et al. (2014) Serum carbon isotope values change in adults in response to changes in sugar-sweetened beverage intake. J Nutr 144:902-5
Anderson, Cheryl A M (2014) Beyond the clinic: importance of community involvement in sodium-reduction efforts. J Public Health Manag Pract 20:S6-8
Hutfless, Susan; Gudzune, Kimberly A; Maruthur, Nisa et al. (2013) Strategies to prevent weight gain in adults: a systematic review. Am J Prev Med 45:e41-51
Strom, Brian L; Anderson, Cheryl A M; Ix, Joachim H (2013) Sodium reduction in populations: insights from the Institute of Medicine committee. JAMA 310:31-2
Anderson, Cheryl A M; Ix, Joachim H (2013) Sodium reduction in CKD: suggestively hazardous or intuitively advantageous? J Am Soc Nephrol 24:1931-3
Anderson, Cheryl A M; Beresford, Shirley A A; McLerran, Dale et al. (2013) Response of serum and red blood cell folate concentrations to folic acid supplementation depends on methylenetetrahydrofolate reductase C677T genotype: results from a crossover trial. Mol Nutr Food Res 57:637-44
Scialla, Julia J; Anderson, Cheryl A M (2013) Dietary acid load: a novel nutritional target in chronic kidney disease? Adv Chronic Kidney Dis 20:141-9
Scialla, Julia J; Appel, Lawrence J; Astor, Brad C et al. (2012) Net endogenous acid production is associated with a faster decline in GFR in African Americans. Kidney Int 82:106-12
Scialla, Julia J; Appel, Lawrence J; Wolf, Myles et al. (2012) Plant protein intake is associated with fibroblast growth factor 23 and serum bicarbonate levels in patients with chronic kidney disease: the Chronic Renal Insufficiency Cohort study. J Ren Nutr 22:379-388.e1

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