This K01 application is designed to prepare the applicant for a successful, independently-funded research career applying methods of stakeholder engagement to investigate the epidemiology of trauma, specifically psychiatric disturbances following TBI. Psychiatric disturbances such as depression, anxiety, and post- traumatic stress disorder (PTSD) following traumatic brain injury (TBI) are associated with poorer cognitive and functional recovery and efficacious treatment would likely improve outcomes. The long term goal of the proposed research is to advance the conduct of patient-centered outcomes research on treatment for psychiatric disturbances following TBI to improve the quality of care. The primary objective of this application is to prioritize patient-selected strategies to overcome barriers to receipt of treatment for psychiatric disturbances following TBI.
The specific aims are: 1) Assess patient-centered barriers and facilitators of treatments across comparator treatments and patient groups; 2) Evaluate current treatment patterns and comparative safety associated with treatment of psychiatric disturbances following TBI; and 3) Prioritize patient-selected strategies to overcome barriers to the receipt of treatment for specifi comparator treatments and populations. Two approaches will be employed to identify barriers and facilitators of the receipt of treatment for the three most common psychiatric disturbances following TBI (depression, anxiety, and PTSD). I will implement training in methods of patient engagement and work with my PCOR advisory committee and mentors to identify and recruit patient partners, including individuals with TBI, their family members, and healthcare providers. We will use focus groups and interviews to assess patient-centered barriers and facilitators of treatments across comparator treatments and patient groups and identify comparator treatments for psychiatric disturbances for comparative safety analyses. Next, I will quantify disparities in treatment patterns associated with the three most common psychiatric disturbances following TBI and perform comparative safety analyses to identify variation of treatment risk among defined subgroups. Finally, I will work with my PCOR advisory committee to prioritize patient-selected strategies to overcome barriers to the receipt of treatment for psychiatric disturbances following TBI. The proposed research employs the best of qualitative and quantitative approaches to assess the treatment of psychiatric disturbances following TBI. Patients with TBI will form part of a research advisory committee that will be actively engaged throughout the research process and will drive research questions. The significance of this research is that it will improve the quality of care for patients with psychiatric disturbances following TBI by prioritizing patient-selected strategies to overcome barriers to the receipt of treatment, and providing needed information on treatment patterns and safety of current pharmacologic treatments.
Psychiatric disturbances such as depression, anxiety, and post-traumatic stress disorder following traumatic brain injury (TBI) are associated with poorer cognitive and functional recovery and efficacious treatment would likely improve outcomes. This project aims to prioritize patient-selected strategies to overcome barriers to the receipt of treatment for psychiatric disturbances following TBI and provide needed information on safety and patterns of current pharmacologic treatments, which is relevant to AHRQ's mission to produce evidence to make health care safer and of higher quality. The ultimate goal of this project is to advance the conduct of patient-centered outcomes research on treatment for psychiatric disturbances following TBI to improve the quality of care.
| Wickwire, Emerson M; Schnyer, David M; Germain, Anne et al. (2018) Sleep, Sleep Disorders, and Circadian Health following Mild Traumatic Brain Injury in Adults: Review and Research Agenda. J Neurotrauma 35:2615-2631 |
| Albrecht, Jennifer S; Hanna, Maya; Kim, Dure et al. (2018) Increased Health Care Utilization in Dementia Subtypes Before Diagnosis. Alzheimer Dis Assoc Disord 32:326-332 |
| Albrecht, Jennifer S; Hanna, Maya; Kim, Dure et al. (2018) Predicting Diagnosis of Alzheimer's Disease and Related Dementias Using Administrative Claims. J Manag Care Spec Pharm 24:1138-1145 |
| Albrecht, Jennifer S; Afshar, Majid; Stein, Deborah M et al. (2018) Association of Alcohol With Mortality After Traumatic Brain Injury. Am J Epidemiol 187:233-241 |
| Albrecht, Jennifer S; Barbour, Lauren; Abariga, Samuel A et al. (2018) Risk of Depression after Traumatic Brain Injury in a Large National Sample. J Neurotrauma : |
| Albrecht, Jennifer S; Wickwire, Emerson M; Vadlamani, Aparna et al. (2018) Trends in Insomnia Diagnosis and Treatment Among Medicare Beneficiaries, 2006-2013. Am J Geriatr Psychiatry : |
| Albrecht, Jennifer S; Rao, Vani; Perfetto, Eleanor M et al. (2018) Safety of Antidepressant Classes Used Following Traumatic Brain Injury Among Medicare Beneficiaries: A Retrospective Cohort Study. Drugs Aging 35:763-772 |
| Albrecht, Jennifer S; Mullins, Daniel C; Smith, Gordon S et al. (2017) Psychotropic Medication Use among Medicare Beneficiaries Following Traumatic Brain Injury. Am J Geriatr Psychiatry 25:415-424 |
| Albrecht, Jennifer S; Slejko, Julia F; Stein, Deborah M et al. (2017) Treatment Charges for Traumatic Brain Injury Among Older Adults at a Trauma Center. J Head Trauma Rehabil 32:E45-E53 |
| Albrecht, Jennifer S; Peters, Matthew E; Smith, Gordon S et al. (2017) Anxiety and Posttraumatic Stress Disorder Among Medicare Beneficiaries After Traumatic Brain Injury. J Head Trauma Rehabil 32:178-184 |
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